Search Keyword:


Search option:


IID00902
 UniprotQ8TD19
ProteinSerine/threonine-protein kinase Nek9
GeneNEK9
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
979
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 940-950 Hetero tetramer : P63167
 Evidence X-RAY 3zkf F Reference
       Region 3zkf F 940-949 order
       Region 3zkf F 950-950 disorder
 Evidence X-RAY 3zkf L Reference
       Region 3zkf L 940-949 order
       Region 3zkf L 950-950 disorder
 Evidence X-RAY 3zkf B Reference
       Region 3zkf B 940-949 order
       Region 3zkf B 950-950 disorder
 Evidence X-RAY 3zkf D Reference
       Region 3zkf D 940-949 order
       Region 3zkf D 950-950 disorder
 Evidence X-RAY 3zkf H Reference
       Region 3zkf H 940-949 order
       Region 3zkf H 950-950 disorder
 Evidence X-RAY 3zkf J Reference
       Region 3zkf J 940-949 order
       Region 3zkf J 950-950 disorder
Seq 940-950 Hetero dodecamer : P63167
 Evidence X-RAY 3zke L Reference
       Region 3zke L 940-950 order
 Evidence X-RAY 3zke J Reference
       Region 3zke J 940-950 order
 Evidence X-RAY 3zke H Reference
       Region 3zke H 940-950 order
 Evidence X-RAY 3zke F Reference
       Region 3zke F 940-940 disorder
       Region 3zke F 941-950 order
 Evidence X-RAY 3zke D Reference
       Region 3zke D 940-950 order
 Evidence X-RAY 3zke B Reference
       Region 3zke B 940-950 order
SeqProS predicted 940-950 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : P63167
       Region 3zkf B 940-949 order
       Region 3zkf D 940-949 order
       Region 3zkf F 940-949 order
       Region 3zkf H 940-949 order
       Region 3zkf J 940-949 order
       Region 3zkf L 940-949 order
SeqProS predicted 940-950 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dodecamer : P63167
       Region 3zke B 940-950 order
       Region 3zke D 940-950 order
       Region 3zke F 941-950 order
       Region 3zke H 940-950 order
       Region 3zke J 940-950 order
       Region 3zke L 940-950 order
Seqphosphorylation
    869-869 Phosphoserine
    868-868 Phosphoserine
    886-886 Phosphothreonine
    944-944 Phosphoserine
    978-978 Phosphoserine
    29-29 Phosphoserine
    2-2 Phosphoserine
    13-13 Phosphoserine
    16-16 Phosphoserine
    20-20 Phosphoserine
    832-832 Phosphoserine
    52-52 Phosphotyrosine
    76-76 Phosphoserine
    210-210 Phosphothreonine; by autocatalysis
    254-254 Phosphothreonine
    331-331 Phosphoserine
    333-333 Phosphothreonine
    741-741 Phosphoserine
    801-801 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-48,321-404,688-693,735-808,814-891,932-965,970-979
Order 49-320,405-572,578-687,694-734,809-813,892-931,966-969
ProS 1-20,321-329,348-358,363-393,401-404,735-755,769-793,804-808,814-826,840-850,877-881,891-891,932-965,970-979
AlphaFold
Disorder 1-47,61-63,196-198,200-213,325-337,365-369,398-399,570-578,685-694,705-707,735-810,812-892,935-979
Order 48-60,64-195,199-199,214-324,338-364,370-397,400-569,579-684,695-704,708-734,811-811,893-934
Pfam Hmmer
PF00069 52-308 7.3e-68
PF00415 444-495 5.7e-05
PF00415 500-547 0.00019
SEG 16-35 ,301-317 ,638-649 ,747-770
Function
Function in SwissProt
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158).