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IID00904
 UniprotQ9NRQ2
ProteinPhospholipid scramblase 4
GenePLSCR4
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
329
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 271-283 Hetero dimer : IID50009Complex
 Evidence X-RAY 3q5u B Reference
       Region 3q5u B 271-272 disorder
       Region 3q5u B 273-280 order
       Region 3q5u B 281-283 disorder
SeqProS possible 273-280 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 3q5u B 273-280 order
Seqphosphorylation
    88-88 Phosphotyrosine; by ABL
    83-83 Phosphotyrosine; by ABL
 
Prediction
NeProc
Disorder 1-106,325-329
Order 107-324
ProS 1-10,24-43,68-71,78-87
AlphaFold
Disorder 1-95,129-139,162-168,170-170,195-201,251-255,281-288,322-329
Order 96-128,140-161,169-169,171-194,202-250,256-280,289-321
Pfam Hmmer
PF03803 100-322 1.9e-134
SEG 22-31 ,39-55 ,191-203
Function
Function in SwissProt
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.