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IID00905
 UniprotQ9UQ13
ProteinLeucine-rich repeat protein SHOC-2
GeneSHOC2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
582
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-582 Homo tetramer :
 Evidence X-RAY 7sd1 A Reference
       Region 7sd1 A 2-84 disorder
       Region 7sd1 A 85-581 order
       Region 7sd1 A 582-582 disorder
 Evidence X-RAY 7sd1 B Reference
       Region 7sd1 B 2-84 disorder
       Region 7sd1 B 85-582 order
 Evidence X-RAY 7sd1 C Reference
       Region 7sd1 C 2-84 disorder
       Region 7sd1 C 85-582 order
 Evidence X-RAY 7sd1 D Reference
       Region 7sd1 D 2-84 disorder
       Region 7sd1 D 85-582 order
Seq 2-582 Hetero hexamer : IID00311Complex,O14807
 Evidence X-RAY 7tvf A Reference
       Region 7tvf A 2-61 disorder
       Region 7tvf A 62-77 order
       Region 7tvf A 78-85 disorder
       Region 7tvf A 86-582 order
 Evidence X-RAY 7tvf D Reference
       Region 7tvf D 2-59 disorder
       Region 7tvf D 60-76 order
       Region 7tvf D 77-80 disorder
       Region 7tvf D 81-578 order
       Region 7tvf D 579-582 disorder
Seq 59-564 Monomer :
 Evidence X-RAY 7tvg D Reference
       Region 7tvg D 59-84 disorder
       Region 7tvg D 85-564 order
Seq 80-582 Homo dimer :
 Evidence X-RAY 7t7a A Reference
       Region 7t7a A 88-581 order
 Evidence X-RAY 7t7a B Reference
       Region 7t7a B 88-579 order
       Region 7t7a B 580-581 disorder
 Evidence X-RAY 7tyg A Reference
       Region 7tyg A 80-85 disorder
       Region 7tyg A 86-579 order
       Region 7tyg A 580-582 disorder
 Evidence X-RAY 7tyg B Reference
       Region 7tyg B 80-88 disorder
       Region 7tyg B 89-581 order
       Region 7tyg B 582-582 disorder
Seq 80-582 Hetero hexamer : IID00311Complex,O14807
 Evidence X-RAY 7txh B Reference
       Region 7txh B 80-85 disorder
       Region 7txh B 86-581 order
       Region 7txh B 582-582 disorder
 Evidence X-RAY 7txh E Reference
       Region 7txh E 80-86 disorder
       Region 7txh E 87-582 order
SeqProS verified 60-77 Hetero hexamer : IID00311Complex,O14807
       Region 7tvf A 62-77 order
       Region 7tvf D 60-76 order
       Region 7tvg D 59-84 disorder
 
Prediction
NeProc
Disorder 1-59
Order 60-582
ProS 5-16,47-59
AlphaFold
Disorder 1-85,578-582
Order 86-577
SEG 46-60 ,281-297 ,309-318 ,325-338 ,491-509 ,516-530
Function
Function in SwissProt
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Biological Process
See also
Diagram with PDB data
RAF1/YWHAZHuman 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A