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IID50005  Protein C-ets-1 (Mus musculus) P27577
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
440
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 29-138 Monomer :
 Evidence NMR 2kmd A Reference
       Region 2kmd A 29-138 order
       Region 2kmd A 29-51 high_rmsd
       Region 2kmd A 137-138 high_rmsd
 Evidence NMR 2jv3 A Reference
       Region 2jv3 A 29-138 order
       Region 2jv3 A 29-37 high_rmsd
Seq 280-440 Hetero dimer : IID00067Complex
 Evidence X-RAY 1k78 F Reference
       Region 1k78 F 331-333 disorder
       Region 1k78 F 334-436 order
       Region 1k78 F 437-440 disorder
 Evidence X-RAY 1mdm B Reference
       Region 1mdm B 280-308 disorder
       Region 1mdm B 309-437 order
       Region 1mdm B 438-440 disorder
Seq 300-440 Homo dimer :
 Evidence X-RAY 1md0 A Reference
       Region 1md0 A 300-437 order
       Region 1md0 A 438-440 disorder
 Evidence X-RAY 1md0 B Reference
       Region 1md0 B 300-437 order
       Region 1md0 B 438-440 disorder
Seq 301-440 Monomer :
 Evidence X-RAY 1k79 A Reference
       Region 1k79 A 331-332 disorder
       Region 1k79 A 333-436 order
       Region 1k79 A 437-440 disorder
 Evidence X-RAY 1k79 D Reference
       Region 1k79 D 331-332 disorder
       Region 1k79 D 333-436 order
       Region 1k79 D 437-440 disorder
 Evidence X-RAY 1k7a A Reference
       Region 1k7a A 331-332 disorder
       Region 1k7a A 333-436 order
       Region 1k7a A 437-440 disorder
 Evidence X-RAY 1k7a D Reference
       Region 1k7a D 331-332 disorder
       Region 1k7a D 333-436 order
       Region 1k7a D 437-440 disorder
 Evidence NMR 1r36 A Reference
       Region 1r36 A 301-440 order
       Region 1r36 A 440-440 high_rmsd
Seq 331-440 Hetero dimer : IID00067Complex
 Evidence X-RAY 1k78 B Reference
       Region 1k78 B 331-334 disorder
       Region 1k78 B 335-436 order
       Region 1k78 B 437-440 disorder
SeqProS verified 300-308 This region is disordered in the complex with DNA, and ordered in the absence of DNA by binding upon Ets1 tiself. Homo dimer :
       Region 1md0 A 300-437 order
       Region 1md0 B 300-437 order
       Region 1mdm B 280-308 disorder
Seqphosphorylation
    38-38 Phosphothreonine; by MAPK
    223-223 Phosphotyrosine
    251-251 Phosphoserine
    254-254 Phosphoserine
    265-265 Phosphothreonine
    267-267 Phosphoserine
    270-270 Phosphoserine
    282-282 Phosphoserine
    285-285 Phosphoserine
Seqacetylation
    8-8 N6-acetyllysine; alternate
    15-15 N6-acetyllysine; alternate
    305-305 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-28,139-296,437-440
Known Domain 29-138,297-436
SCOPe RPS-Blast
     4mhvA 44-136 4e-34 a.60.1.0 automated matches
     4co8A1 333-428 2e-53 a.4.5.0 automated matches
SCOP Hmmer
     1bqvA_ 30-135 1.8e-37 a.60.1.1 Ets DNA-binding ...
     1md0A_ 303-435 2.2e-53 a.4.5.21 E74-like factor...
Pfam RPS-Blast
     PF02198 64-135 1e-20 Sterile alpha motif (SAM)/Po...
     PF00178 336-414 5e-23 Ets-domain
Pfam Hmmer
    PF02198 54-135 2e-38 Sterile alpha motif (SAM)/Poi...
    PF00178 336-415 7.1e-41 Ets-domain