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IID50024
 UniprotQ60795
ProteinNuclear factor erythroid 2-related factor 2
GeneNfe2l2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
597
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-98
 Evidence NMR Reference
       Region 1-98 disorder
Seq 17-51 Hetero dimer : IID50109Complex
 Evidence X-RAY 3wn7 M Reference
       Region 3wn7 M 17-40 order
       Region 3wn7 M 41-51 disorder
 Evidence X-RAY 3wn7 B Reference
       Region 3wn7 B 17-40 order
       Region 3wn7 B 41-51 disorder
Seq 22-36 Hetero dimer : IID50109Complex
 Evidence X-RAY 2dyh B Reference
       Region 2dyh B 22-23 disorder
       Region 2dyh B 24-29 order
       Region 2dyh B 30-36 disorder
Seq 76-84 Hetero dimer : IID50109Complex
 Evidence X-RAY 1x2r B Reference
       Region 1x2r B 76-84 order
SeqProS verified 17-40 Hetero dimer : IID50109Complex
       Region 3wn7 B 17-40 order
       Region 3wn7 M 17-40 order
       Region 1-98 disorder
SeqProS verified 24-29 Hetero dimer : IID50109Complex
       Region 2dyh B 24-29 order
       Region 1-98 disorder
SeqProS verified 76-84 Hetero dimer : IID50109Complex
       Region 1x2r B 76-84 order
       Region 1-98 disorder
Seqphosphorylation
    207-207 Phosphoserine
    40-40 Phosphoserine; by PKC
Seqacetylation
    591-591 N6-acetyllysine; by CREBBP
    588-588 N6-acetyllysine; by CREBBP
 
Prediction
NeProc
Disorder 1-16,41-444,589-597
Order 17-40,445-588
ProS 11-16,41-48,56-87,111-140,176-205,219-223,231-246,275-281,294-341,355-395,432-444
AlphaFold
Disorder 1-12,87-114,128-170,189-444,590-597
Order 13-86,115-127,171-188,445-589
SEG 43-68
Function
Function in SwissProt
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.