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IID50053
 UniprotQ61036
ProteinSerine/threonine-protein kinase PAK 3
GenePak3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
559
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 63-93,101-123 Hetero dimer : IID00308Complex
 Evidence NMR 1ees B Reference
       Region 1ees B 63-92 order
       Region 1ees B 63-71 high_rmsd
       Region 1ees B 88-93 high_rmsd
       Region 1ees B 101-108 high_rmsd
       Region 1ees B 108-123 order
Seqdisorder 65-92,108-123
 Evidence NMR Reference
       Region 65-92 disorder
       Region 108-123 disorder
Seqphosphorylation
    436-436 Phosphothreonine; by autocatalysis
    186-186 Phosphoserine
    154-154 Phosphoserine; by autocatalysis
    50-50 Phosphoserine; by autocatalysis
    4-4 Phosphoserine
    2-2 Phosphoserine
 
Prediction
NeProc
Disorder 1-75,97-105,139-261,554-559
Order 76-96,106-138,262-553
ProS 1-18,69-75,139-143,150-162,206-211,243-247,257-261
AlphaFold
Disorder 1-81,93-108,141-259,559-559
Order 82-92,109-140,260-558
Pfam Hmmer
PF00786 69-142 2.8e-26
PF00069 283-534 5.9e-100
SEG 187-204
Function
Function in SwissProt
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.