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IID50055
 UniprotQ8K4J6
ProteinMKL/myocardin-like protein 1
GeneMrtfa
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
964
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 16-41 Hetero tetramer : IID50082Complex
 Evidence X-RAY 2v51 F Reference
       Region 2v51 F 16-40 order
       Region 2v51 F 41-41 disorder
 Evidence X-RAY 2v51 E Reference
       Region 2v51 E 16-40 order
       Region 2v51 E 41-41 disorder
Seq 16-142 Hetero tetramer : IID50082Complex
 Evidence X-RAY 2yje M Reference
       Region 2yje M 16-63 order
       Region 2yje M 64-142 disorder
Seq 16-142 Hetero hexamer : IID50082Complex
 Evidence X-RAY 2yjf M Reference
       Region 2yjf M 16-126 order
       Region 2yjf M 127-142 disorder
Seqdisorder 16-142
 Evidence CD Reference
       Region 16-142 disorder
Seq 54-85 Hetero dimer : IID50082Complex
 Evidence X-RAY 2v52 M Reference
       Region 2v52 M 54-83 order
       Region 2v52 M 84-85 disorder
SeqProS verified 16-40 This region (54-83) is ordered in the complex with monomeric actin. Hetero tetramer : IID50082Complex
       Region 2v51 E 16-40 order
       Region 2v51 F 16-40 order
       Region 16-142 disorder
SeqProS verified 16-63 This region (16-63) is ordered in the complex with trimeric actin. Hetero tetramer : IID50082Complex
       Region 2yje M 16-63 order
       Region 16-142 disorder
SeqProS verified 16-126 This region (16-126) is ordered in the complex with pentameric actin. Hetero hexamer : IID50082Complex
       Region 2yjf M 16-126 order
       Region 16-142 disorder
SeqProS verified 54-83 This region (16-40) is ordered in the complex with monomeric actin. Hetero dimer : IID50082Complex
       Region 2v52 M 54-83 order
       Region 16-142 disorder
Seqphosphorylation
    842-842 Phosphothreonine
    892-892 Phosphoserine
    351-351 Phosphoserine
    840-840 Phosphoserine
    349-349 Phosphoserine
    191-191 Phosphoserine
    174-174 Phosphoserine
    159-159 Phosphoserine
    41-41 Phosphoserine
    530-530 Phosphoserine
    355-355 Phosphoserine
    358-358 Phosphoserine
    360-360 Phosphothreonine
    371-371 Phosphoserine
    423-423 Phosphoserine
    484-484 Phosphoserine
    485-485 Phosphothreonine
    487-487 Phosphoserine
    488-488 Phosphothreonine
    492-492 Phosphoserine
    494-494 Phosphothreonine
    496-496 Phosphoserine
    520-520 Phosphoserine
    352-352 Phosphothreonine
    544-544 Phosphoserine
    548-548 Phosphoserine
    605-605 Phosphoserine
    606-606 Phosphoserine
    651-651 Phosphoserine
    687-687 Phosphoserine
    718-718 Phosphoserine
    724-724 Phosphoserine
    728-728 Phosphoserine
    810-810 Phosphoserine
    822-822 Phosphothreonine
    826-826 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,25-559,599-951,961-964
Order 15-24,560-598,952-960
ProS 1-14,25-37,48-65,70-81,96-126,132-140,153-160,394-401,773-776,781-787,844-848,873-898,910-927,944-951,961-964
AlphaFold
Disorder 1-4,129-271,273-273,275-276,278-291,318-379,423-557,597-692,702-777,797-871,882-964
Order 5-128,272-272,274-274,277-277,292-317,380-422,558-596,693-701,778-796,872-881
Pfam Hmmer
PF02755 59-84 0.0003
PF02755 103-128 0.00083
PF02037 385-419 9.3e-14
SEG 146-159 ,209-228 ,259-272 ,298-320 ,340-365 ,424-433 ,483-496 ,578-600 ,670-679 ,714-735
Function
Function in SwissProt
Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.