Search Keyword:


Search option:


IID50066
 UniprotP06494
ProteinReceptor tyrosine-protein kinase erbB-2
GeneErbb2
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1257
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 23-631 Monomer :
 Evidence X-RAY 1n8y C GenBank 22651765 Reference
       Region 1n8y C 23-123 order
       Region 1n8y C 124-134 disorder
       Region 1n8y C 135-275 order
       Region 1n8y C 276-280 disorder
       Region 1n8y C 281-631 order
Seq 647-681 Monomer :
 Evidence NMR 1iij A Reference
       Region 1iij A 647-681 order
Seqphosphorylation
    1250-1250 Phosphotyrosine; by autocatalysis
    1198-1198 Phosphotyrosine
    1141-1141 Phosphotyrosine; by autocatalysis
    1168-1168 Phosphothreonine
    1114-1114 Phosphotyrosine
    1109-1109 Phosphoserine
    1085-1085 Phosphoserine
    1080-1080 Phosphoserine
    879-879 Phosphotyrosine
    1056-1056 Phosphoserine
 
Prediction
NeProc
Disorder 1-20,638-654,1014-1227,1232-1240
Order 21-125,133-637,655-1013,1228-1231,1241-1257
ProS 4-20,638-654,1018-1036,1055-1057,1071-1075,1086-1100,1111-1201,1216-1227,1232-1240
AlphaFold
Disorder 1-23,122-134,503-503,606-614,630-660,682-714,731-733,758-769,771-772,866-885,992-1020,1022-1257
Order 24-121,135-502,504-605,615-629,661-681,715-730,734-757,770-770,773-865,886-991,1021-1021
Pfam Hmmer
PF01030 52-174 2e-39
PF00757 190-344 6.6e-93
PF01030 367-487 5.3e-33
PF07714 722-978 8.4e-134
SEG 453-468 ,660-686 ,1041-1077 ,1147-1164 ,1206-1219
Function
Function in SwissProt
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth (By similarity).