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IID50066  Receptor tyrosine-protein kinase erbB-2 (Rattus norvegicus) P06494
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
xml
Experiment
1257
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 23-631 Monomer :
 Evidence X-RAY 1n8y C Reference
       Region 1n8y C 23-123 order
       Region 1n8y C 124-134 disorder
       Region 1n8y C 135-275 order
       Region 1n8y C 276-280 disorder
       Region 1n8y C 281-631 order
Seq 647-681 Monomer :
 Evidence NMR 1iij A Reference
       Region 1iij A 647-681 order
Seqphosphorylation
    1056-1056 Phosphoserine
    1080-1080 Phosphoserine
    1085-1085 Phosphoserine
    1109-1109 Phosphoserine
    1114-1114 Phosphotyrosine
    1141-1141 Phosphotyrosine; by autocatalysis
    1168-1168 Phosphothreonine
    1198-1198 Phosphotyrosine
    1250-1250 Phosphotyrosine; by autocatalysis
 
Prediction
DICHOT
Disorder 1-22,632-654,678-708,996-1257
Known Domain 23-631,655-677,709-995
SCOPe RPS-Blast
     3h3bA1 23-188 2e-40 c.10.2.5 EGF receptor extracellular domain
     1n8yC3 188-344 6e-45 g.3.9.1 EGF receptor Cys-rich domains
     1n8yC2 345-511 2e-37 c.10.2.5 EGF receptor extracellular domain
     1n8yC4 512-631 1e-35 g.3.9.1 EGF receptor Cys-rich domains
     3pozA 711-1026 e-158 d.144.1.7 3-phosphoinositide dependent protein...
SCOP Hmmer
     1n8yC1 24-200 7.3e-43 c.10.2.5 EGF receptor ext...
     1n8yC3 190-344 7.1e-18 g.3.9.1 EGF receptor Cys...
     1n8zC2 338-527 1.9e-42 c.10.2.5 EGF receptor ex...
     1m6bB4 512-644 3e-23 g.3.9.1 EGF receptor Cys-r...
     1m14A_ 718-1000 1.5e-79 d.144.1.7 3-phosphoinos...
Pfam RPS-Blast
     PF01030 52-172 8e-11 Receptor L domain
     PF00757 186-344 1e-40 Furin-like cysteine rich re...
     PF01030 367-486 4e-18 Receptor L domain
     PF14843 512-644 7e-28 Growth factor receptor doma...
     PF06293 798-882 5e-04 Lipopolysaccharide kinase (...
     PF00859 998-1177 5e-05 CTF/NF-I family transcript...
Pfam Hmmer
    PF01030 52-172 3e-34 Receptor L domain
    PF00757 191-344 2.4e-28 Furin-like cysteine rich r...
    PF01030 367-486 2.4e-24 Receptor L domain
    PF14843 512-644 1.9e-45 Growth factor receptor dom...
    PF07714 723-977 1.8e-89 Protein tyrosine kinase