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IID50091  Tyrosine-protein kinase JAK2 (Mus musculus) Q62120
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
1129
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 810-820 Hetero dimer : IID50098Complex
 Evidence X-RAY 2hdx G Reference
       Region 2hdx G 810-818 order
       Region 2hdx G 819-820 disorder
 Evidence X-RAY 2hdx H Reference
       Region 2hdx H 810-811 disorder
       Region 2hdx H 812-818 order
       Region 2hdx H 819-820 disorder
 Evidence X-RAY 2hdx I Reference
       Region 2hdx I 810-811 disorder
       Region 2hdx I 812-818 order
       Region 2hdx I 819-820 disorder
 Evidence X-RAY 2hdx J Reference
       Region 2hdx J 810-811 disorder
       Region 2hdx J 812-818 order
       Region 2hdx J 819-820 disorder
 Evidence X-RAY 2hdx K Reference
       Region 2hdx K 810-811 disorder
       Region 2hdx K 812-818 order
       Region 2hdx K 819-820 disorder
 Evidence X-RAY 2hdx L Reference
       Region 2hdx L 810-818 order
       Region 2hdx L 819-820 disorder
Seq 836-1129 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 D Reference
       Region 4gl9 D 836-842 disorder
       Region 4gl9 D 843-919 order
       Region 4gl9 D 920-923 disorder
       Region 4gl9 D 924-1127 order
       Region 4gl9 D 1128-1129 disorder
Seq 836-1129 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 A Reference
       Region 4gl9 A 836-842 disorder
       Region 4gl9 A 843-919 order
       Region 4gl9 A 920-923 disorder
       Region 4gl9 A 924-1127 order
       Region 4gl9 A 1128-1129 disorder
Seq 836-1129 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 C Reference
       Region 4gl9 C 836-842 disorder
       Region 4gl9 C 843-919 order
       Region 4gl9 C 920-923 disorder
       Region 4gl9 C 924-1127 order
       Region 4gl9 C 1128-1129 disorder
Seq 836-1129 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 B Reference
       Region 4gl9 B 836-842 disorder
       Region 4gl9 B 843-919 order
       Region 4gl9 B 920-923 disorder
       Region 4gl9 B 924-1050 order
       Region 4gl9 B 1051-1052 disorder
       Region 4gl9 B 1053-1127 order
       Region 4gl9 B 1128-1129 disorder
Seqphosphorylation
    119-119 Phosphotyrosine; by autocatalysis
    372-372 Phosphotyrosine
    373-373 Phosphotyrosine
    523-523 Phosphoserine
    570-570 Phosphotyrosine
    813-813 Phosphotyrosine
    868-868 Phosphotyrosine; by autocatalysis
    966-966 Phosphotyrosine; by autocatalysis
    972-972 Phosphotyrosine; by autocatalysis
    1007-1007 Phosphotyrosine; by autocatalysis
    1008-1008 Phosphotyrosine; by autocatalysis
 
Prediction
DICHOT
Disorder 1-42,514-534,1127-1129
Known Domain 43-513,535-1126
SCOPe RPS-Blast
     2oq1A1 401-503 3e-07 d.93.1.1 Abl tyrosine kinase
     5ut3A 537-808 e-101 d.144.1.0 automated matches
     3lxpA 840-1126 e-121 d.144.1.0 automated matches
SCOP Hmmer
     2al6A1 141-261 9.4e-10 a.11.2.1 Erythroid membr...
     2al6A2 279-386 6.1e-19 b.55.1.5 Erythroid membr...
     1a81A1 396-563 1.4e-20 d.93.1.1 Abl tyrosine ki...
     1r0pA_ 523-814 9.5e-50 d.144.1.7 3-phosphoinosi...
     1rjbA_ 842-1119 4.5e-73 d.144.1.7 3-phosphoinos...
Pfam RPS-Blast
     PF18379 75-103 4e-09 FERM F1 ubiquitin-like domai...
     PF18377 143-261 1e-39 FERM F2 acyl-CoA binding pr...
     PF17887 271-381 2e-26 Jak1 pleckstrin homology-li...
     PF14531 971-1048 2e-04 Kinase-like
Pfam Hmmer
    PF18379 39-134 6.2e-44 FERM F1 ubiquitin-like doma...
    PF18377 143-261 4.8e-48 FERM F2 acyl-CoA binding p...
    PF17887 302-381 1.4e-23 Jak1 pleckstrin homology-l...
    PF00017 401-481 1.5e-09 SH2 domain
    PF07714 546-805 1.7e-63 Protein tyrosine kinase
    PF07714 849-1120 6.7e-89 Protein tyrosine kinase