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IID50093
 UniprotQ6PB44
ProteinTyrosine-protein phosphatase non-receptor type 23
GenePtpn23
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1692
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 719-730 Hetero dimer : IID50062Complex
 Evidence X-RAY 2w10 C Reference
       Region 2w10 C 719-728 order
       Region 2w10 C 729-730 disorder
 Evidence X-RAY 2w10 D Reference
       Region 2w10 D 719-730 order
Seqphosphorylation
    744-744 Phosphothreonine
    1178-1178 Phosphoserine
    1179-1179 Phosphoserine
    1187-1187 Phosphothreonine
 
Prediction
NeProc
Disorder 1-5,477-479,481-488,712-1215,1520-1692
Order 6-476,480-480,489-545,551-711,1216-1519
ProS 1-5,477-479,481-481,712-712,854-860,868-871,886-891,911-917,959-965,972-980,1200-1205,1539-1547,1634-1670,1675-1692
AlphaFold
Disorder 405-407,409-410,476-489,712-1212,1241-1244,1519-1692
Order 1-404,408-408,411-475,490-711,1213-1240,1245-1518
Pfam Hmmer
PF03097 8-384 2.2e-181
PF00102 1273-1507 3.6e-94
SEG 462-479 ,715-728 ,774-785 ,849-858 ,905-928 ,977-1018 ,1040-1061 ,1088-1106 ,1128-1160 ,1185-1200 ,1225-1235 ,1576-1587 ,1589-1643 ,1675-1689
Function
Function in SwissProt
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity).