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IID50097
 UniprotQ8R316
ProteinHMG box-containing protein 1
GeneHbp1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
516
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 208-345 Monomer :
 Evidence NMR 1v06 A Reference
       Region 1v06 A 208-345 order
Seq 358-380 Hetero dimer : IID50089Complex
 Evidence NMR 1s5r A Reference
       Region 1s5r A 358-380 order
       Region 1s5r A 358-358 high_rmsd
       Region 1s5r A 379-380 high_rmsd
Seqdisorder 358-380
 Evidence CD Reference
       Region 358-380 disorder
SeqProS verified 358-380 Hetero dimer : IID50089Complex
       Region 1s5r A 358-380 order
       Region 358-380 disorder
 
Prediction
NeProc
Disorder 9-53,62-68,83-103,111-120,126-198,241-254,330-434,506-516
Order 1-8,54-61,74-82,105-110,121-125,199-240,255-329,435-477,483-505
ProS 14-22,31-53,62-68,83-89,111-120,126-129,137-152,167-171,177-182,241-248,330-336,353-364
AlphaFold
Disorder 1-108,119-205,227-228,242-253,255-255,344-365,372-372,379-379,381-437,502-516
Order 109-118,206-226,229-241,254-254,256-343,366-371,373-378,380-380,438-501
Pfam Hmmer
PF08517 215-340 3e-81
PF00505 436-505 1.7e-13
SEG 152-166 ,396-414
Function
Function in SwissProt
Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
Biological Process
Diagram with PDB data
Hbp1/Sin3aSolution Structure of HBP1 SID-mSin3A PAH2 Complex