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IID50109
 UniprotQ9Z2X8
ProteinKelch-like ECH-associated protein 1
GeneKeap1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
624
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 309-624 Hetero dimer : IID50024Complex
 Evidence X-RAY 2dyh A Reference
       Region 2dyh A 309-323 disorder
       Region 2dyh A 324-619 order
       Region 2dyh A 620-624 disorder
Seq 309-624 Hetero dimer : IID50024Complex
 Evidence X-RAY 1x2r A Reference
       Region 1x2r A 309-323 disorder
       Region 1x2r A 324-613 order
       Region 1x2r A 614-624 disorder
Seq 309-624 Hetero dimer : IID50035Complex
 Evidence X-RAY 2z32 A Reference
       Region 2z32 A 309-323 disorder
       Region 2z32 A 324-613 order
       Region 2z32 A 614-624 disorder
Seq 309-624 Monomer :
 Evidence X-RAY 1x2j A Reference
       Region 1x2j A 309-323 disorder
       Region 1x2j A 324-613 order
       Region 1x2j A 614-624 disorder
 Evidence X-RAY 4zy3 A Reference
       Region 4zy3 A 321-324 disorder
       Region 4zy3 A 325-609 order
 Evidence X-RAY 4zy3 B Reference
       Region 4zy3 B 321-324 disorder
       Region 4zy3 B 325-609 order
 Evidence X-RAY 5cgj A Reference
       Region 5cgj A 309-323 disorder
       Region 5cgj A 324-613 order
       Region 5cgj A 614-624 disorder
 Evidence X-RAY 5fnq A Reference
       Region 5fnq A 322-323 disorder
       Region 5fnq A 324-613 order
       Region 5fnq A 614-624 disorder
 Evidence X-RAY 5fnr A Reference
       Region 5fnr A 322-324 disorder
       Region 5fnr A 325-613 order
       Region 5fnr A 614-624 disorder
 Evidence X-RAY 5fns A Reference
       Region 5fns A 322-324 disorder
       Region 5fns A 325-613 order
       Region 5fns A 614-624 disorder
 Evidence X-RAY 5fnt A Reference
       Region 5fnt A 322-324 disorder
       Region 5fnt A 325-613 order
       Region 5fnt A 614-624 disorder
 Evidence X-RAY 5fnu A Reference
       Region 5fnu A 322-325 disorder
       Region 5fnu A 326-613 order
       Region 5fnu A 614-624 disorder
 Evidence X-RAY 5fzj A Reference
       Region 5fzj A 322-324 disorder
       Region 5fzj A 325-613 order
       Region 5fzj A 614-624 disorder
 Evidence X-RAY 5fzn A Reference
       Region 5fzn A 322-323 disorder
       Region 5fzn A 324-613 order
       Region 5fzn A 614-624 disorder
Seq 309-624 Hetero dimer : IID50150Complex
 Evidence X-RAY 3ade A Reference
       Region 3ade A 309-324 disorder
       Region 3ade A 325-613 order
       Region 3ade A 614-624 disorder
 Evidence X-RAY 3wdz A Reference
       Region 3wdz A 321-324 disorder
       Region 3wdz A 325-609 order
Seq 321-609 Hetero dimer : IID50024Complex
 Evidence X-RAY 3wn7 A Reference
       Region 3wn7 A 321-323 disorder
       Region 3wn7 A 324-609 order
 Evidence X-RAY 3wn7 L Reference
       Region 3wn7 L 321-323 disorder
       Region 3wn7 L 324-609 order
 
Prediction
NeProc
Disorder 1-50,621-624
Order 51-311,317-620
ProS 26-31,621-624
AlphaFold
Disorder 1-51,314-318,620-624
Order 52-313,319-619
Pfam Hmmer
PF00651 67-179 4.6e-41
PF07707 184-286 6.1e-48
PF01344 315-359 8.7e-06
PF01344 361-410 1.4e-15
PF01344 412-457 4.1e-14
PF01344 459-504 2e-16
PF01344 506-551 1.1e-18
PF01344 553-598 1.1e-17
Function
Function in SwissProt
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.