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IID50118  Tyrosine-protein kinase ITK/TSK (Mus musculus) Q03526
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
625
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 160-238 Monomer :
 Evidence NMR 1awj A Reference
       Region 1awj A 160-236 order
 Evidence NMR 2rn8 A Reference
       Region 2rn8 A 177-238 order
 Evidence NMR 2rna A Reference
       Region 2rna A 177-238 order
Seq 177-344 Hetero dimer :
 Evidence NMR 2k79 A Reference
       Region 2k79 A 177-237 order
 Evidence NMR 2k7a A Reference
       Region 2k7a A 177-237 order
 Evidence NMR 2k79 B Reference
       Region 2k79 B 238-344 order
 Evidence NMR 2k7a B Reference
       Region 2k7a B 238-344 order
Seq 236-344 Monomer :
 Evidence X-RAY 3s9k A Reference
       Region 3s9k A 236-238 disorder
       Region 3s9k A 239-344 order
 Evidence NMR 1lui A Reference
       Region 1lui A 238-344 order
 Evidence NMR 1luk A Reference
       Region 1luk A 238-344 order
 Evidence NMR 1lum A Reference
       Region 1lum A 238-344 order
       Region 1lum A 288-288 high_rmsd
 Evidence NMR 1lun A Reference
       Region 1lun A 238-344 order
Seq 238-344 Hetero dimer : IID50090Complex
 Evidence NMR 2etz A Reference
       Region 2etz A 238-344 order
 Evidence NMR 2eu0 A Reference
       Region 2eu0 A 238-344 order
Seqphosphorylation
    186-186 Phosphotyrosine; by autocatalysis
    517-517 Phosphotyrosine; by LCK
    570-570 Phosphoserine
 
Prediction
DICHOT
Disorder 1-4,623-625
Known Domain 5-622
SCOPe RPS-Blast
     1btkA 5-153 1e-29 b.55.1.1 3-phosphoinositide dependent protein kina...
     2yuqA1 168-245 3e-27 b.34.2.1 53BP2
     3s9kA1 239-344 7e-43 d.93.1.1 Abl tyrosine kinase
     4rfzA 363-622 e-125 d.144.1.7 3-phosphoinositide dependent protein ...
SCOP Hmmer
     1btkA_ 6-153 6.8e-43 b.55.1.1 3-phosphoinositid...
     1kjwA1 181-262 2.3e-17 b.34.2.1 53BP2
     1a81A1 240-387 1.5e-32 d.93.1.1 Abl tyrosine ki...
     1m14A_ 357-618 3.9e-78 d.144.1.7 3-phosphoinosi...
Pfam RPS-Blast
     PF00779 125-154 5e-09 BTK motif
     PF17902 162-229 1e-06 SH3 domain
     PF00017 245-328 2e-06 SH2 domain
Pfam Hmmer
    PF00169 7-114 3.8e-15 PH domain
    PF00779 125-153 9.6e-16 BTK motif
    PF00018 183-229 8.8e-16 SH3 domain
    PF00017 245-328 3e-25 SH2 domain
    PF07714 368-617 3e-95 Protein tyrosine kinase