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IID50142
 UniprotP45446
ProteinNuclear receptor ROR-beta
GeneRorb
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
470
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 212-470 Hetero dimer : IID00083Complex
 Evidence X-RAY 1k4w A Reference
       Region 1k4w A 212-218 disorder
       Region 1k4w A 219-462 order
       Region 1k4w A 463-463 disorder
 Evidence X-RAY 1n4h A Reference
       Region 1n4h A 212-218 disorder
       Region 1n4h A 219-462 order
       Region 1n4h A 463-470 disorder
 Evidence X-RAY 1nq7 A Reference
       Region 1nq7 A 219-462 order
 
Prediction
NeProc
Disorder 1-15,83-93,133-255,466-470
Order 16-82,94-132,256-465
ProS 91-93,167-172,179-202,211-218,224-255,466-470
AlphaFold
Disorder 1-15,91-96,121-217,463-470
Order 16-90,97-120,218-462
Pfam Hmmer
PF00105 19-94 7e-56
PF00104 278-460 3.4e-46
SEG 109-122 ,134-145
Function
Function in SwissProt
Isoform 1
Critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment