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IID50144
 UniprotP61965
ProteinWD repeat-containing protein 5
GeneWdr5
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
334
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-334 Hetero trimer : IID50152Complex,P68433
 Evidence X-RAY 2xl3 B Reference
       Region 2xl3 B 1-30 disorder
       Region 2xl3 B 31-334 order
 Evidence X-RAY 2xl3 A Reference
       Region 2xl3 A 1-31 disorder
       Region 2xl3 A 32-334 order
Seq 1-334 Hetero dimer : IID50152Complex
 Evidence X-RAY 2xl2 B Reference
       Region 2xl2 B 1-30 disorder
       Region 2xl2 B 31-334 order
 Evidence X-RAY 2xl2 A Reference
       Region 2xl2 A 1-30 disorder
       Region 2xl2 A 31-334 order
Seqacetylation
    2-2 N-acetylalanine
    112-112 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-23
Order 24-334
ProS 23-23
AlphaFold
Disorder 1-28,30-30
Order 29-29,31-334
Pfam Hmmer
PF00400 35-73 9.5e-12
PF00400 77-115 1.9e-11
PF00400 119-157 4.6e-13
PF00400 161-199 2.6e-12
PF00400 203-242 9.8e-07
PF00400 246-287 2e-07
SEG 2-15
Function
Function in SwissProt
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.