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IID50170
 UniprotP32447
ProteinHistone chaperone ASF1
GeneASF1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
279
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-156 Hetero trimer :
 Evidence X-RAY 5eii G Reference
       Region 5eii G 1-1 disorder
       Region 5eii G 2-45 order
       Region 5eii G 46-53 disorder
       Region 5eii G 54-153 order
       Region 5eii G 154-156 disorder
Seq 1-156 Hetero dimer : IID50168Complex
 Evidence X-RAY 2ygv D Reference
       Region 2ygv D 1-51 order
       Region 2ygv D 52-53 disorder
       Region 2ygv D 54-154 order
       Region 2ygv D 155-156 disorder
 Evidence X-RAY 2ygv C Reference
       Region 2ygv C 1-155 order
       Region 2ygv C 156-156 disorder
 Evidence X-RAY 2ygv B Reference
       Region 2ygv B 1-155 order
       Region 2ygv B 156-156 disorder
 Evidence X-RAY 2ygv A Reference
       Region 2ygv A 1-1 disorder
       Region 2ygv A 2-155 order
       Region 2ygv A 156-156 disorder
Seq 1-156 Hetero trimer :
 Evidence X-RAY 5eii I Reference
       Region 5eii I 1-1 disorder
       Region 5eii I 2-45 order
       Region 5eii I 46-53 disorder
       Region 5eii I 54-88 order
       Region 5eii I 89-96 disorder
       Region 5eii I 97-114 order
       Region 5eii I 115-134 disorder
       Region 5eii I 135-153 order
       Region 5eii I 154-156 disorder
Seq 1-169 Monomer :
 Evidence X-RAY 1wg3 A Reference
       Region 1wg3 A 1-160 order
       Region 1wg3 A 161-169 disorder
 Evidence X-RAY 1roc A Reference
       Region 1roc A 2-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 6ayz A Reference
       Region 6ayz A 2-30 order
       Region 6ayz A 31-34 disorder
       Region 6ayz A 35-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 6az2 D Reference
       Region 6az2 D 2-46 order
       Region 6az2 D 47-53 disorder
       Region 6az2 D 54-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 5ucb B Reference
       Region 5ucb B 2-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 5uea X Reference
       Region 5uea X 2-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 6az2 B Reference
       Region 6az2 B 2-46 order
       Region 6az2 B 47-53 disorder
       Region 6az2 B 54-80 order
       Region 6az2 B 81-90 disorder
       Region 6az2 B 91-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 6ayz M Reference
       Region 6ayz M 2-153 order
       Region 6ayz M 154-154 disorder
Seq 2-154 Hetero trimer :
 Evidence X-RAY 5uek A Reference
       Region 5uek A 2-154 order
Seq 2-154 Hetero trimer :
 Evidence X-RAY 5uea D Reference
       Region 5uea D 2-46 order
       Region 5uea D 47-54 disorder
       Region 5uea D 55-80 order
       Region 5uea D 81-90 disorder
       Region 5uea D 91-154 order
Seq 2-155 Monomer : IID50143Complex
 Evidence X-RAY 2idc A Reference
       Region 2idc A 2-155 order
Seq 2-169 Hetero dimer :
 Evidence NMR 6f0y A Reference
       Region 6f0y A 2-169 order
       Region 6f0y A 157-169 high_rmsd
Seq 2-169 Hetero trimer : IID50145Complex,IID50147Complex
 Evidence X-RAY 2hue A Reference
       Region 2hue A 2-164 order
       Region 2hue A 165-169 disorder
 Evidence X-RAY 4eo5 A Reference
       Region 4eo5 A 2-155 order
       Region 4eo5 A 156-158 disorder
       Region 4eo5 A 159-164 order
       Region 4eo5 A 165-169 disorder
Seq 2-169 Hetero tetramer : IID50145Complex,Q10453
 Evidence X-RAY 4zbj A Reference
       Region 4zbj A 2-154 order
       Region 4zbj A 155-169 disorder
 
Prediction
NeProc
Disorder 157-186,250-279
Order 1-156,187-249
ProS 268-273
AlphaFold
Disorder 156-257,261-279
Order 1-155,258-260
Pfam Hmmer
PF04729 1-155 3.2e-123
SEG 170-242
Function
Function in SwissProt
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Facilitates histone deposition through both replication-dependent and replication-independent chromatin assembly pathways. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with the HIR complex to promote replication-independent chromatin assembly, which may occur during transcription and DNA repair. May be required for the maintenance of a subset of replication elongation factors, including DNA polymerase epsilon, the RFC complex and PCNA, at stalled replication forks. Also required for acetylation of histone H3 on 'Lys-9' and 'Lys-56'.