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IID50199
 UniprotP15379
ProteinCD44 antigen
GeneCd44
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
778
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 21-174 Monomer :
 Evidence X-RAY 5bzc A Reference
       Region 5bzc A 22-171 order
 Evidence X-RAY 5bze A Reference
       Region 5bze A 23-171 order
 Evidence X-RAY 5bzf A Reference
       Region 5bzf A 21-21 disorder
       Region 5bzf A 22-171 order
 Evidence X-RAY 5bzg A Reference
       Region 5bzg A 21-21 disorder
       Region 5bzg A 22-171 order
 Evidence X-RAY 5bzh A Reference
       Region 5bzh A 21-21 disorder
       Region 5bzh A 22-171 order
 Evidence X-RAY 5bzi A Reference
       Region 5bzi A 21-21 disorder
       Region 5bzi A 22-171 order
 Evidence X-RAY 5bzj A Reference
       Region 5bzj A 21-21 disorder
       Region 5bzj A 22-171 order
 Evidence X-RAY 5bzk A Reference
       Region 5bzk A 21-21 disorder
       Region 5bzk A 22-171 order
 Evidence X-RAY 5bzl A Reference
       Region 5bzl A 21-21 disorder
       Region 5bzl A 22-171 order
 Evidence X-RAY 5bzm A Reference
       Region 5bzm A 21-21 disorder
       Region 5bzm A 22-171 order
 Evidence X-RAY 5bzn A Reference
       Region 5bzn A 21-21 disorder
       Region 5bzn A 22-171 order
 Evidence X-RAY 5bzo A Reference
       Region 5bzo A 21-21 disorder
       Region 5bzo A 22-171 order
 Evidence X-RAY 5bzp A Reference
       Region 5bzp A 21-21 disorder
       Region 5bzp A 22-171 order
 Evidence X-RAY 5bzq A Reference
       Region 5bzq A 21-21 disorder
       Region 5bzq A 22-171 order
 Evidence X-RAY 5bzr A Reference
       Region 5bzr A 21-21 disorder
       Region 5bzr A 22-171 order
 Evidence X-RAY 5bzs A Reference
       Region 5bzs A 21-21 disorder
       Region 5bzs A 22-171 order
 Evidence X-RAY 5bzt A Reference
       Region 5bzt A 21-21 disorder
       Region 5bzt A 22-171 order
 Evidence X-RAY 2jcp A Reference
       Region 2jcp A 23-171 order
       Region 2jcp A 172-174 disorder
 Evidence X-RAY 4mre A Reference
       Region 4mre A 23-171 order
 Evidence X-RAY 4mrf A Reference
       Region 4mrf A 23-171 order
 Evidence X-RAY 4mrg A Reference
       Region 4mrg A 23-171 order
 Evidence X-RAY 4mrh A Reference
       Region 4mrh A 23-171 order
 Evidence X-RAY 4np2 A Reference
       Region 4np2 A 23-171 order
 Evidence X-RAY 4np3 A Reference
       Region 4np3 A 23-171 order
 Evidence X-RAY 2jcq A Reference
       Region 2jcq A 23-171 order
       Region 2jcq A 172-174 disorder
 Evidence X-RAY 2jcr A Reference
       Region 2jcr A 23-171 order
       Region 2jcr A 172-174 disorder
 Evidence X-RAY 4mrd A Reference
       Region 4mrd A 23-171 order
Seq 708-727 Hetero dimer : IID50114Complex
 Evidence X-RAY 2zpy B Reference
       Region 2zpy B 708-713 disorder
       Region 2zpy B 714-722 order
       Region 2zpy B 723-727 disorder
Seqphosphorylation
    726-726 Phosphothreonine
    733-733 Phosphoserine
    742-742 Phosphoserine
    708-708 Phosphoserine; by PKC
 
Prediction
NeProc
Disorder 1-19,135-685,709-778
Order 20-133,686-708
ProS 1-19,135-161,193-223,242-248,257-260,281-288,328-334,354-377,385-390,398-406,435-444,458-463,482-496,515-535,557-564,569-585,591-612,628-643,652-659,681-685,709-727,735-778
AlphaFold
Disorder 1-2,16-21,174-682,711-778
Order 3-15,22-173,683-710
Pfam Hmmer
PF00193 33-122 1.4e-39
SEG 249-274 ,315-328 ,427-437 ,638-651 ,687-701
Function
Function in SwissProt
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity). Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (PubMed:25065622).