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IID50205  Talin-1 (Mus musculus) P26039
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
2541
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-85 Monomer :
 Evidence NMR 2kc1 A Reference
       Region 2kc1 A 1-34 order
       Region 2kc1 A 35-45 disorder
       Region 2kc1 A 46-50 order
       Region 2kc1 A 51-59 disorder
       Region 2kc1 A 60-85 order
Seq 1-86 Hetero dimer : P61224
 Evidence NMR 6ba6 A Reference
       Region 6ba6 A 1-86 order
Seq 1-138,169-202 Monomer :
 Evidence NMR 2kma A Reference
       Region 2kma A 1-138 order
       Region 2kma A 169-202 order
       Region 2kma A 172-172 high_rmsd
Seq 1-138,168-400 Monomer :
 Evidence X-RAY 3ivf A Reference
       Region 3ivf A 1-1 disorder
       Region 3ivf A 2-133 order
       Region 3ivf A 134-138 disorder
       Region 3ivf A 168-172 disorder
       Region 3ivf A 173-398 order
       Region 3ivf A 399-400 disorder
Seq 86-202 Monomer :
 Evidence NMR 2kc2 A Reference
       Region 2kc2 A 86-202 order
       Region 2kc2 A 135-166 high_rmsd
       Region 2kc2 A 198-202 high_rmsd
Seqdisorder 145-168
 Evidence CD Reference
       Region 145-168 disorder
Seq 206-405,1654-1847 Hetero dimer :
 Evidence X-RAY 4f7g A Reference
       Region 4f7g A 206-208 disorder
       Region 4f7g A 209-400 order
       Region 4f7g A 401-405 disorder
 Evidence X-RAY 4f7g B Reference
       Region 4f7g B 1654-1654 disorder
       Region 4f7g B 1655-1824 order
       Region 4f7g B 1825-1847 disorder
Seq 209-410 Hetero dimer : IID50194Complex
 Evidence X-RAY 1y19 B Reference
       Region 1y19 B 209-400 order
       Region 1y19 B 401-410 disorder
 Evidence X-RAY 1y19 D Reference
       Region 1y19 D 209-400 order
       Region 1y19 D 401-410 disorder
 Evidence X-RAY 1y19 F Reference
       Region 1y19 F 209-400 order
       Region 1y19 F 401-410 disorder
 Evidence X-RAY 1y19 H Reference
       Region 1y19 H 209-400 order
       Region 1y19 H 401-410 disorder
 Evidence X-RAY 1y19 J Reference
       Region 1y19 J 209-400 order
       Region 1y19 J 401-410 disorder
 Evidence X-RAY 1y19 L Reference
       Region 1y19 L 209-400 order
       Region 1y19 L 401-410 disorder
Seq 305-404 Hetero dimer : IID00359Complex
 Evidence NMR 2g35 A Reference
       Region 2g35 A 305-404 order
Seq 311-401,1655-1822 Hetero dimer :
 Evidence NMR 2kgx A Reference
       Region 2kgx A 1655-1822 order
 Evidence NMR 2kgx B Reference
       Region 2kgx B 311-401 order
Seqdisorder 316-326
 Evidence NMR Reference
       Region 316-326 disorder
Seqdisorder 400-480
 Evidence NMR Reference
       Region 400-480 disorder
Seq 482-655 Monomer :
 Evidence X-RAY 1sj7 A Reference
       Region 1sj7 A 482-487 disorder
       Region 1sj7 A 488-654 order
       Region 1sj7 A 655-655 disorder
 Evidence X-RAY 1sj7 B Reference
       Region 1sj7 B 482-484 disorder
       Region 1sj7 B 485-654 order
       Region 1sj7 B 655-655 disorder
 Evidence X-RAY 1sj7 C Reference
       Region 1sj7 C 482-488 disorder
       Region 1sj7 C 489-654 order
       Region 1sj7 C 655-655 disorder
Seq 482-789 Monomer :
 Evidence X-RAY 1sj8 A Reference
       Region 1sj8 A 482-485 disorder
       Region 1sj8 A 486-782 order
       Region 1sj8 A 783-789 disorder
Seq 605-628 Hetero dimer : P12003
 Evidence X-RAY 1t01 B Reference
       Region 1t01 B 605-628 order
Seqdisorder 635-654
 Evidence NMR Reference
       Region 635-654 disorder
Seq 755-889 Monomer :
 Evidence NMR 1u89 A Reference
       Region 1u89 A 755-889 order
       Region 1u89 A 755-760 high_rmsd
       Region 1u89 A 791-794 high_rmsd
       Region 1u89 A 880-889 high_rmsd
Seq 787-911 Monomer :
 Evidence NMR 2l7a A Reference
       Region 2l7a A 787-911 order
       Region 2l7a A 787-795 high_rmsd
       Region 2l7a A 911-911 high_rmsd
Seq 913-1044 Monomer :
 Evidence NMR 2lqg A Reference
       Region 2lqg A 913-1044 order
       Region 2lqg A 941-948 high_rmsd
Seq 1046-1207 Monomer :
 Evidence NMR 2l7n A Reference
       Region 2l7n A 1046-1207 order
       Region 2l7n A 1046-1047 high_rmsd
       Region 2l7n A 1108-1113 high_rmsd
       Region 2l7n A 1207-1207 high_rmsd
Seq 1206-1357 Monomer :
 Evidence NMR 2l10 A Reference
       Region 2l10 A 1206-1357 order
       Region 2l10 A 1230-1232 high_rmsd
       Region 2l10 A 1356-1357 high_rmsd
Seq 1357-1657 Hetero dimer : Q8R5A3
 Evidence X-RAY 4w8p A Reference
       Region 4w8p A 1357-1657 order
Seq 1357-1822 Monomer :
 Evidence X-RAY 5ic0 A Reference
       Region 5ic0 A 1357-1819 order
       Region 5ic0 A 1820-1822 disorder
 Evidence X-RAY 5ic1 A Reference
       Region 5ic1 A 1357-1819 order
       Region 5ic1 A 1820-1822 disorder
Seq 1359-1659 Hetero dimer : IID00677Complex
 Evidence X-RAY 5fzt A Reference
       Region 5fzt A 1359-1659 order
Seq 1359-1659 Monomer :
 Evidence X-RAY 2x0c A Reference
       Region 2x0c A 1359-1659 order
Seq 1512-1546 Hetero dimer : P18206
 Evidence X-RAY 3s90 C Reference
       Region 3s90 C 1512-1519 disorder
       Region 3s90 C 1520-1546 order
 Evidence X-RAY 3s90 D Reference
       Region 3s90 D 1512-1519 disorder
       Region 3s90 D 1520-1545 order
       Region 3s90 D 1546-1546 disorder
Seq 1628-1652 Hetero dimer : P12003
 Evidence X-RAY 1zw3 B Reference
       Region 1zw3 B 1628-1629 disorder
       Region 1zw3 B 1630-1652 order
Seq 1655-1822 Monomer :
 Evidence NMR 2kbb A Reference
       Region 2kbb A 1655-1822 order
Seq 1815-1973 Monomer :
 Evidence NMR 2b0h A Reference
       Region 2b0h A 1843-1973 order
       Region 2b0h A 1843-1846 high_rmsd
       Region 2b0h A 1973-1973 high_rmsd
 Evidence NMR 2kvp A Reference
       Region 2kvp A 1815-1973 order
       Region 2kvp A 1815-1822 high_rmsd
       Region 2kvp A 1973-1973 high_rmsd
Seqdisorder 1910-1939
 Evidence EPR This region is described to be disordered in the complex with vinculin. Reference
       Region 1910-1939 disorder
Seq 1974-2293 Monomer :
 Evidence X-RAY 3dyj A Reference
       Region 3dyj A 1974-1974 disorder
       Region 3dyj A 1975-2291 order
       Region 3dyj A 2292-2293 disorder
 Evidence X-RAY 3dyj B Reference
       Region 3dyj B 1974-1974 disorder
       Region 3dyj B 1975-2291 order
       Region 3dyj B 2292-2293 disorder
Seq 2300-2482 Monomer :
 Evidence NMR 2jsw A Reference
       Region 2jsw A 2300-2482 order
       Region 2jsw A 2331-2336 high_rmsd
       Region 2jsw A 2482-2482 high_rmsd
Seq 2494-2541 Homo dimer :
 Evidence X-RAY 2qdq A Reference
       Region 2qdq A 2494-2495 disorder
       Region 2qdq A 2496-2529 order
       Region 2qdq A 2530-2541 disorder
 Evidence X-RAY 2qdq B Reference
       Region 2qdq B 2494-2496 disorder
       Region 2qdq B 2497-2529 order
       Region 2qdq B 2530-2541 disorder
SeqProS verified 316-326 This region is ordered in the complex with another region of this protein. Hetero dimer :
       Region 2kgx B 311-401 order
       Region 316-326 disorder
SeqProS verified 1910-1939 This region is described to be disordered in the complex with vinculin. :
       Region 2kvp A 1815-1973 order
       Region 2b0h A 1843-1973 order
       Region 1910-1939 disorder
Seqphosphorylation
    167-167 Phosphothreonine
    405-405 Phosphoserine
    425-425 Phosphoserine
    446-446 Phosphoserine
    620-620 Phosphoserine
    729-729 Phosphoserine
    1021-1021 Phosphoserine
    1116-1116 Phosphotyrosine
    1142-1142 Phosphothreonine
    1201-1201 Phosphoserine
    1225-1225 Phosphoserine
    1263-1263 Phosphothreonine
    1323-1323 Phosphoserine
    1328-1328 Phosphoserine
    1849-1849 Phosphoserine
    1855-1855 Phosphothreonine
    1878-1878 Phosphoserine
    2040-2040 Phosphoserine
Seqacetylation
    1544-1544 N6-acetyllysine
    2031-2031 N6-acetyllysine
    2115-2115 N6-acetyllysine
 
Prediction
DICHOT
Disorder 1-1,399-485,783-786,912-946,1045-1045,1817-1837,1974-1974,2290-2295,2483-2541
Known Domain 2-398,486-782,787-911,947-1044,1046-1816,1838-1973,1975-2289,2296-2482
SCOPe RPS-Blast
     1mixA1 196-308 1e-47 a.11.2.1 Erythroid membrane protein 4.1R
     1mixA2 309-400 9e-37 b.55.1.5 Erythroid membrane protein 4.1R
     1sj7A1 488-654 5e-44 a.215.1.1 A middle domain of Talin 1
     1sj8A2 658-782 5e-29 a.216.1.1 Huntingtin interacting protein 12
     1u89A1 755-889 8e-34 a.216.1.1 Huntingtin interacting protein 12
     1sj8A2 952-1041 1e-05 a.216.1.1 Huntingtin interacting protein 12
     1u89A1 1092-1184 7e-06 a.216.1.1 Huntingtin interacting protein 12
     2b0hA1 1231-1350 2e-09 a.24.9.2 Talin 1
     2b0hA1 1843-1973 3e-37 a.24.9.2 Talin 1
     2b0hA1 2007-2134 1e-07 a.24.9.2 Talin 1
     1r0dA 2296-2486 4e-43 a.216.1.1 Huntingtin interacting protein 12
SCOP Hmmer
     1wgrA_ 79-135 1.5e-08 Ubiquitin-like
     1mixA1 195-308 7.3e-36 a.11.2.1 Erythroid membr...
     1mixA2 309-399 1.8e-28 b.55.1.5 Erythroid membr...
     1sj7A1 488-653 7.3e-74 a.215.1.1 A middle domai...
     1sj8A2 658-782 8.4e-50 a.216.1.1 Huntingtin int...
     1u89A1 753-888 9e-56 a.216.1.1 Huntingtin inter...
     1sj8A2 853-942 0.00089 a.216.1.1 Huntingtin int...
     1sj8A2 949-1042 3.9e-06 a.216.1.1 Huntingtin in...
     2b0hA1 1075-1207 1.1e-29 a.24.9.2 Talin 1
     2b0hA1 1225-1361 2.3e-41 a.24.9.2 Talin 1
     1r0dA_ 1411-1555 1.3e-14 a.216.1.1 Huntingtin i...
     2b0hA1 1598-1658 8.4e-06 a.24.9.2 Talin 1
     2b0hA1 1695-1814 2.6e-09 a.24.9.2 Talin 1
     2b0hA1 1841-1973 9.8e-49 a.24.9.2 Talin 1
     2b0hA1 2010-2132 9.5e-09 a.24.9.2 Talin 1
     1u89A1 2103-2227 0.00081 a.216.1.1 Huntingtin i...
     1r0dA_ 2295-2486 7.9e-53 a.216.1.1 Huntingtin i...
Pfam RPS-Blast
     PF16511 12-82 2e-19 N-terminal or F0 domain of Ta...
     PF09379 90-163 9e-09 FERM N-terminal domain
     PF00373 207-313 5e-14 FERM central domain
     PF02174 313-397 4e-09 PTB domain (IRS-1 type)
     PF09141 491-652 2e-37 Talin, middle domain
     PF01608 661-760 6e-12 I/LWEQ domain
     PF08913 1094-1203 8e-06 Vinculin Binding Site
     PF08913 1234-1353 7e-18 Vinculin Binding Site
     PF08913 1849-1973 1e-34 Vinculin Binding Site
     PF08913 2011-2134 2e-05 Vinculin Binding Site
     PF01608 2385-2479 2e-15 I/LWEQ domain
Pfam Hmmer
    PF16511 4-83 4.1e-35 N-terminal or F0 domain of Ta...
    PF09379 90-186 1e-33 FERM N-terminal domain
    PF00373 206-313 1.8e-30 FERM central domain
    PF09141 491-652 1.8e-59 Talin, middle domain
    PF08913 1849-1973 9.2e-66 Vinculin Binding Site
    PF01608 2386-2531 5.4e-53 I/LWEQ domain