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IID50211
 UniprotP45448
ProteinNuclear receptor subfamily 5 group A member 2
GeneNr5a2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
560
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 313-560 Monomer :
 Evidence X-RAY 1pk5 B Reference
       Region 1pk5 B 313-318 disorder
       Region 1pk5 B 319-352 order
       Region 1pk5 B 353-357 disorder
       Region 1pk5 B 358-559 order
       Region 1pk5 B 560-560 disorder
 Evidence X-RAY 1pk5 A Reference
       Region 1pk5 A 313-317 disorder
       Region 1pk5 A 318-559 order
       Region 1pk5 A 560-560 disorder
Seq 313-560 Hetero trimer : IID50228Complex
 Evidence X-RAY 3f5c A Reference
       Region 3f5c A 313-317 disorder
       Region 3f5c A 318-560 order
Seq 318-560 Hetero dimer : IID50220Complex
 Evidence X-RAY 1zh7 B Reference
       Region 1zh7 B 318-560 order
 Evidence X-RAY 1zh7 A Reference
       Region 1zh7 A 318-560 order
 
Prediction
NeProc
Disorder 1-102,178-358
Order 103-177,359-560
ProS 7-18,178-199,276-281,292-297,322-344
AlphaFold
Disorder 1-104,184-184,211-318,352-358,438-438,547-548
Order 105-183,185-210,319-351,359-437,439-546,549-560
Pfam Hmmer
PF00105 105-180 2.9e-51
PF00104 369-554 2.7e-57
SEG 290-302
Function
Function in SwissProt
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544).