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IID50221  Low-density lipoprotein receptor-related protein 2 (Rattus norvegicus) P98158
  :order  :disorder  :conflict  :PDB cluster  :ProS  :SCOP Domain  :Pfam Domain
Networkxml
Experiment
4660
fasta
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1185-1229 Monomer :
 Evidence NMR 2i1p A Reference
       Region 2i1p A 1185-1229 order
       Region 2i1p A 1185-1185 high_rmsd
       Region 2i1p A 1225-1229 high_rmsd
Seq 4448-4466 Hetero dimer : Q9H9E1
 Evidence X-RAY 3v2o B Reference
       Region 3v2o B 4448-4455 disorder
       Region 3v2o B 4456-4466 order
 Evidence X-RAY 3v2x B Reference
       Region 3v2x B 4455-4465 order
Seqphosphorylation
    4464-4464 Phosphoserine
    4467-4467 Phosphoserine
    4577-4577 Phosphoserine
    4624-4624 Phosphoserine
    4637-4637 Phosphothreonine
    4658-4658 Phosphoserine
 
Prediction
DICHOT
Disorder 1-24,1013-1020,1102-1121,1743-1769,2060-2063,2726-2740,3512-3513,3702-3717,4403-4424,4448-4660
Known Domain 25-1012,1021-1101,1122-1742,1770-2059,2064-2725,2741-2818,2862-3511,3514-3701,3718-4358,4425-4447
Cryptic Domain 2819-2861,4359-4402
SCOPe RPS-Blast
     2fcwB1 26-63 2e-10 g.12.1.1 Extracellular hemoglobin linker l2 subu...
     2fcwB1 65-103 7e-07 g.12.1.1 Extracellular hemoglobin linker l2 sub...
     2fcwB1 107-142 7e-10 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 146-181 7e-05 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 183-217 7e-10 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 221-256 9e-10 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2gtlM2 263-298 3e-04 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1ijqA1 393-658 3e-93 b.68.5.1 Low density lipoprotein (LDL) receptor
     1ijqA2 657-705 1e-08 g.3.11.1 Activated protein c (autoprothrombin I...
     1ijqA1 709-967 9e-79 b.68.5.1 Low density lipoprotein (LDL) receptor
     1ijqA2 971-1012 5e-08 g.3.11.1 Activated protein c (autoprothrombin ...
     2fcwB1 1023-1059 7e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1065-1103 2e-10 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1109-1144 5e-11 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1149-1184 6e-10 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1187-1225 5e-09 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1231-1264 3e-07 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 1270-1308 5e-13 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2gtlM2 1312-1347 5e-04 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2y5fL 1353-1409 5e-07 g.3.11.1 Activated protein c (autoprothrombin...
     1dx5I3 1391-1428 2e-09 g.3.11.1 Activated protein c (autoprothrombin...
     1ijqA1 1437-1699 e-107 b.68.5.1 Low density lipoprotein (LDL) recept...
     1ijqA2 1703-1742 7e-05 g.3.11.1 Activated protein c (autoprothrombin...
     1npeA 1757-2012 5e-50 b.68.5.1 Low density lipoprotein (LDL) recepto...
     2bz6L 2023-2065 1e-06 g.3.11.1 Activated protein c (autoprothrombin...
     1ijqA1 2064-2336 1e-57 b.68.5.1 Low density lipoprotein (LDL) recept...
     1ijqA2 2345-2383 2e-04 g.3.11.1 Activated protein c (autoprothrombin...
     1ijqA1 2390-2650 4e-75 b.68.5.1 Low density lipoprotein (LDL) recept...
     1ijqA2 2654-2694 7e-05 g.3.11.1 Activated protein c (autoprothrombin...
     1j8eA 2701-2738 3e-09 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 2741-2776 1e-09 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 2779-2819 1e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1j8eA 2820-2862 9e-07 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1j8eA 2861-2899 4e-08 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1j8eA 2906-2940 3e-11 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1j8eA 2948-2993 1e-06 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 2993-3029 3e-10 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1j8eA 3034-3070 7e-10 g.12.1.1 Extracellular hemoglobin linker l2 su...
     2fcwB1 3076-3111 2e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1szbA2 3113-3154 9e-10 g.3.11.1 Activated protein c (autoprothrombi...
     1apqA 3153-3194 7e-08 g.3.11.1 Activated protein c (autoprothrombin ...
     1ijqA1 3201-3465 e-116 b.68.5.1 Low density lipoprotein (LDL) recept...
     1ijqA2 3469-3500 2e-06 g.3.11.1 Activated protein c (autoprothrombin...
     2fcwB1 3514-3551 5e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1xfeA2 3558-3591 4e-04 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2gtlM2 3594-3633 1e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1j8eA 3633-3674 7e-13 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1xfeA2 3679-3717 4e-05 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 3721-3756 9e-10 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 3759-3795 3e-12 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 3798-3836 8e-09 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1j8eA 3844-3880 2e-07 g.12.1.1 Extracellular hemoglobin linker l2 su...
     1xfeA2 3884-3922 3e-07 g.12.1.1 Extracellular hemoglobin linker l2 ...
     2fcwB1 3928-3964 2e-08 g.12.1.1 Extracellular hemoglobin linker l2 ...
     1dx5I3 4009-4038 6e-05 g.3.11.1 Activated protein c (autoprothrombin...
     1ijqA1 4056-4327 5e-79 b.68.5.1 Low density lipoprotein (LDL) recept...
SCOP Hmmer
     1jrfA_ 26-62 3.6e-12 LDL receptor-like module
     1jrfA_ 58-101 1e-09 LDL receptor-like module
     1jrfA_ 101-143 1.3e-12 LDL receptor-like modul...
     1jrfA_ 146-180 7.2e-09 LDL receptor-like modul...
     1d2lA_ 181-218 5.8e-10 g.12.1.1 Extracellular h...
     1n7dA7 221-259 2.4e-10 g.12.1.1 Extracellular h...
     1cr8A_ 263-300 7e-10 g.12.1.1 Extracellular hem...
     1kigL_ 315-357 6.6e-06 g.3.11.1 Activated prote...
     1n7dA3 347-382 8.8e-07 g.3.11.1 Activated prote...
     1ijqA1 395-656 1e-47 b.68.5.1 Low density lipop...
     1ijqA2 659-704 2.7e-08 g.3.11.1 Activated prote...
     1ijqA1 709-968 8.9e-46 b.68.5.1 Low density lip...
     1kliL_ 969-1016 2e-05 g.3.11.1 Activated protei...
     1jrfA_ 1021-1059 3.2e-11 LDL receptor-like mod...
     1ldlA_ 1063-1103 3e-11 g.12.1.1 Extracellular h...
     1jrfA_ 1106-1144 4.1e-12 LDL receptor-like mod...
     1jrfA_ 1148-1185 2e-12 LDL receptor-like modul...
     1n7dA7 1187-1225 2.3e-10 g.12.1.1 Extracellular...
     1jrfA_ 1227-1264 1.4e-10 LDL receptor-like mod...
     1jrfA_ 1266-1307 1.1e-12 LDL receptor-like mod...
     1cr8A_ 1311-1347 2.2e-09 g.12.1.1 Extracellular...
     1kigL_ 1354-1398 1.3e-11 g.3.11.1 Activated pro...
     1apqA_ 1383-1430 1.1e-10 g.3.11.1 Activated pro...
     1ijqA1 1439-1700 5.4e-46 b.68.5.1 Low density l...
     1kliL_ 1702-1747 3.6e-06 g.3.11.1 Activated pro...
     1ijqA1 1747-2013 5.6e-39 b.68.5.1 Low density l...
     1kliL_ 2020-2068 8.9e-12 g.3.11.1 Activated pro...
     1ijqA1 2086-2312 3.9e-36 b.68.5.1 Low density l...
     1kliL_ 2343-2388 4.8e-06 g.3.11.1 Activated pro...
     1ijqA1 2390-2634 2.9e-40 b.68.5.1 Low density l...
     1pfxL2 2655-2716 0.00021 g.3.11.1 Activated pro...
     1n7dA7 2700-2744 4.2e-11 g.12.1.1 Extracellular...
     1jrfA_ 2736-2777 6.7e-13 LDL receptor-like mod...
     1jrfA_ 2782-2818 6.8e-09 LDL receptor-like mod...
     1jrfA_ 2814-2860 1.7e-10 LDL receptor-like mod...
     1jrfA_ 2858-2899 2.7e-11 LDL receptor-like mod...
     1ldlA_ 2906-2942 1.8e-11 g.12.1.1 Extracellular...
     1ldlA_ 2945-2989 4.5e-09 g.12.1.1 Extracellular...
     1jrfA_ 2988-3029 1.1e-12 LDL receptor-like mod...
     1jrfA_ 3028-3070 3.1e-12 LDL receptor-like mod...
     1jrfA_ 3071-3111 2.7e-11 LDL receptor-like mod...
     1kigL_ 3122-3161 1.6e-11 g.3.11.1 Activated pro...
     1apqA_ 3146-3194 5.4e-14 g.3.11.1 Activated pro...
     1ijqA1 3201-3465 1.6e-52 b.68.5.1 Low density l...
     1ijqA2 3469-3501 6.7e-05 g.3.11.1 Activated pro...
     1cr8A_ 3512-3548 2e-11 g.12.1.1 Extracellular h...
     1ldlA_ 3550-3591 5.2e-10 g.12.1.1 Extracellular...
     1jrfA_ 3587-3630 1.2e-11 LDL receptor-like mod...
     1jrfA_ 3629-3668 4e-12 LDL receptor-like modul...
     1cr8A_ 3683-3716 1.3e-08 g.12.1.1 Extracellular...
     1n7dAa 3720-3757 1.2e-11 g.12.1.1 Extracellular...
     1jrfA_ 3755-3795 1.3e-11 LDL receptor-like mod...
     1n7dA7 3799-3836 2.1e-11 g.12.1.1 Extracellular...
     1jrfA_ 3842-3876 8.2e-11 LDL receptor-like mod...
     1n7dAa 3884-3922 1.6e-09 g.12.1.1 Extracellular...
     1d2lA_ 3927-3964 1.1e-10 g.12.1.1 Extracellular...
     1zaqA_ 3969-4010 9e-08 g.3.11.1 Activated prote...
     1dx5I3 4009-4042 7e-08 g.3.11.1 Activated prote...
     1ijqA1 4058-4328 3.7e-39 b.68.5.1 Low density l...
     2dtgE6 4328-4413 0.00014 g.3.9.1 EGF receptor C...
Pfam RPS-Blast
     PF00057 28-62 3e-06 Low-density lipoprotein recep...
     PF00057 108-142 2e-06 Low-density lipoprotein rec...
     PF00057 183-217 1e-06 Low-density lipoprotein rec...
     PF00057 222-256 2e-06 Low-density lipoprotein rec...
     PF00058 478-518 2e-06 Low-density lipoprotein rec...
     PF00058 521-564 2e-09 Low-density lipoprotein rec...
     PF00058 795-834 6e-05 Low-density lipoprotein rec...
     PF00058 837-878 6e-10 Low-density lipoprotein rec...
     PF00058 882-921 1e-04 Low-density lipoprotein rec...
     PF00057 1025-1059 1e-05 Low-density lipoprotein r...
     PF00057 1066-1101 2e-05 Low-density lipoprotein r...
     PF00057 1110-1144 1e-07 Low-density lipoprotein r...
     PF00057 1150-1184 6e-07 Low-density lipoprotein r...
     PF00057 1188-1223 2e-04 Low-density lipoprotein r...
     PF00057 1230-1263 2e-04 Low-density lipoprotein r...
     PF00057 1272-1306 7e-07 Low-density lipoprotein r...
     PF14670 1354-1389 8e-04 Coagulation Factor Xa inh...
     PF14670 1399-1429 3e-05 Coagulation Factor Xa inh...
     PF00058 1522-1562 3e-10 Low-density lipoprotein r...
     PF00058 1569-1608 7e-13 Low-density lipoprotein r...
     PF00058 1611-1652 6e-05 Low-density lipoprotein r...
     PF00058 1884-1928 9e-06 Low-density lipoprotein r...
     PF14670 2030-2059 8e-04 Coagulation Factor Xa inh...
     PF00058 2203-2244 3e-11 Low-density lipoprotein r...
     PF00058 2520-2560 3e-13 Low-density lipoprotein r...
     PF00058 2564-2602 3e-05 Low-density lipoprotein r...
     PF00057 2701-2732 1e-05 Low-density lipoprotein r...
     PF00057 2740-2776 1e-06 Low-density lipoprotein r...
     PF00057 2786-2818 3e-04 Low-density lipoprotein r...
     PF00057 2863-2899 1e-04 Low-density lipoprotein r...
     PF00057 2908-2939 6e-07 Low-density lipoprotein r...
     PF00057 2995-3029 2e-06 Low-density lipoprotein r...
     PF00057 3032-3066 6e-07 Low-density lipoprotein r...
     PF00057 3075-3111 1e-06 Low-density lipoprotein r...
     PF14670 3124-3152 3e-04 Coagulation Factor Xa inh...
     PF12662 3134-3157 2e-05 Complement Clr-like EGF-l...
     PF00058 3242-3281 5e-07 Low-density lipoprotein r...
     PF00058 3284-3332 5e-04 Low-density lipoprotein r...
     PF00058 3335-3376 3e-12 Low-density lipoprotein r...
     PF00058 3379-3418 2e-06 Low-density lipoprotein r...
     PF00057 3512-3548 4e-05 Low-density lipoprotein r...
     PF00057 3555-3586 4e-04 Low-density lipoprotein r...
     PF00057 3594-3627 4e-05 Low-density lipoprotein r...
     PF00057 3637-3668 6e-07 Low-density lipoprotein r...
     PF00057 3682-3716 8e-04 Low-density lipoprotein r...
     PF00057 3723-3756 1e-06 Low-density lipoprotein r...
     PF00057 3761-3795 3e-07 Low-density lipoprotein r...
     PF00057 3800-3834 2e-05 Low-density lipoprotein r...
     PF00057 3843-3876 9e-05 Low-density lipoprotein r...
     PF00057 3887-3918 8e-04 Low-density lipoprotein r...
     PF00057 3930-3964 1e-05 Low-density lipoprotein r...
     PF00058 4156-4194 1e-08 Low-density lipoprotein r...
     PF00058 4199-4240 6e-13 Low-density lipoprotein r...
     PF00058 4244-4282 8e-04 Low-density lipoprotein r...
Pfam Hmmer
    PF00057 27-62 1.2e-12 Low-density lipoprotein rece...
    PF00057 66-103 2e-11 Low-density lipoprotein recep...
    PF00057 106-142 1.1e-13 Low-density lipoprotein re...
    PF00057 147-179 7.5e-09 Low-density lipoprotein re...
    PF00057 183-217 1.4e-14 Low-density lipoprotein re...
    PF00057 221-256 1.5e-12 Low-density lipoprotein re...
    PF00057 264-299 5e-10 Low-density lipoprotein rece...
    PF00058 479-518 1.4e-08 Low-density lipoprotein re...
    PF00058 521-564 1.4e-08 Low-density lipoprotein re...
    PF00058 795-834 2.8e-09 Low-density lipoprotein re...
    PF00058 837-878 1.4e-08 Low-density lipoprotein re...
    PF00057 1024-1059 6e-13 Low-density lipoprotein re...
    PF00057 1064-1101 1.2e-14 Low-density lipoprotein ...
    PF00057 1108-1144 1.8e-14 Low-density lipoprotein ...
    PF00057 1149-1184 2.9e-15 Low-density lipoprotein ...
    PF00057 1187-1223 1.7e-13 Low-density lipoprotein ...
    PF00057 1231-1267 2.5e-13 Low-density lipoprotein ...
    PF00057 1270-1306 4.4e-15 Low-density lipoprotein ...
    PF07645 1391-1429 1.5e-09 Calcium-binding EGF doma...
    PF00058 1522-1562 2.9e-13 Low-density lipoprotein ...
    PF00058 1569-1608 5.3e-11 Low-density lipoprotein ...
    PF00058 1884-1929 1.9e-16 Low-density lipoprotein ...
    PF14670 2023-2059 2.6e-13 Coagulation Factor Xa in...
    PF00058 2520-2560 2.4e-12 Low-density lipoprotein ...
    PF00057 2700-2732 7.5e-14 Low-density lipoprotein ...
    PF00057 2741-2776 1.4e-14 Low-density lipoprotein ...
    PF00057 2780-2818 2.2e-11 Low-density lipoprotein ...
    PF00057 2822-2856 4.2e-12 Low-density lipoprotein ...
    PF00057 2864-2901 6.2e-15 Low-density lipoprotein ...
    PF00057 2906-2945 8.5e-15 Low-density lipoprotein ...
    PF00057 2949-2990 8e-12 Low-density lipoprotein re...
    PF00057 2993-3029 2e-14 Low-density lipoprotein re...
    PF00057 3033-3067 8.7e-15 Low-density lipoprotein ...
    PF00057 3076-3111 7e-12 Low-density lipoprotein re...
    PF12662 3134-3157 1.5e-13 Complement Clr-like EGF-...
    PF07645 3154-3193 3.6e-11 Calcium-binding EGF doma...
    PF00058 3242-3281 1.3e-08 Low-density lipoprotein ...
    PF00058 3284-3332 4.1e-14 Low-density lipoprotein ...
    PF00058 3335-3376 8.8e-13 Low-density lipoprotein ...
    PF00058 3380-3418 4e-09 Low-density lipoprotein re...
    PF00057 3514-3548 2.9e-13 Low-density lipoprotein ...
    PF00057 3555-3587 2.7e-10 Low-density lipoprotein ...
    PF00057 3595-3632 8.4e-13 Low-density lipoprotein ...
    PF00057 3635-3673 1.6e-15 Low-density lipoprotein ...
    PF00057 3679-3716 1.1e-10 Low-density lipoprotein ...
    PF00057 3721-3756 4.9e-14 Low-density lipoprotein ...
    PF00057 3760-3795 3.4e-14 Low-density lipoprotein ...
    PF00057 3798-3834 7.5e-15 Low-density lipoprotein ...
    PF00057 3844-3876 1.8e-13 Low-density lipoprotein ...
    PF00057 3885-3922 3.9e-10 Low-density lipoprotein ...
    PF00057 3929-3964 2e-12 Low-density lipoprotein re...
    PF12662 3989-4012 2e-10 Complement Clr-like EGF-li...
    PF07645 4009-4043 1.1e-08 Calcium-binding EGF doma...
    PF00058 4156-4194 1.2e-10 Low-density lipoprotein ...
    PF00058 4199-4240 6.3e-13 Low-density lipoprotein ...