Search Keyword:


Search option:


IID50222
 UniprotQ00560
ProteinInterleukin-6 receptor subunit beta
GeneIl6st
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
917
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 750-764 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 I Reference
       Region 4gl9 I 750-754 disorder
       Region 4gl9 I 755-762 order
       Region 4gl9 I 763-764 disorder
Seq 750-764 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 K Reference
       Region 4gl9 K 750-754 disorder
       Region 4gl9 K 755-762 order
       Region 4gl9 K 763-764 disorder
Seq 750-764 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 L Reference
       Region 4gl9 L 750-754 disorder
       Region 4gl9 L 755-762 order
       Region 4gl9 L 763-764 disorder
Seq 750-764 Hetero dimer : IID50193Complex
 Evidence X-RAY 2hmh B Reference
       Region 2hmh B 753-763 order
 Evidence NMR 2bbu B Reference
       Region 2bbu B 750-764 order
Seq 750-764 Hetero tetramer : IID50193Complex
 Evidence X-RAY 4gl9 J Reference
       Region 4gl9 J 750-753 disorder
       Region 4gl9 J 754-762 order
       Region 4gl9 J 763-764 disorder
Seqphosphorylation
    837-837 Phosphoserine
    827-827 Phosphoserine
    787-787 Phosphoserine
    780-780 Phosphoserine
    665-665 Phosphoserine
    659-659 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,613-617,641-643,654-659,668-917
Order 15-612,618-640,644-653,660-667
ProS 4-14,613-617,641-643,654-659,682-695,702-730,754-767,773-788,809-832,840-847,858-862,881-892,898-917
AlphaFold
Disorder 1-26,109-109,175-176,336-340,641-917
Order 27-108,110-174,177-335,341-640
Pfam Hmmer
PF06328 24-114 1.2e-38
PF00041 220-309 2.3e-10
PF00041 514-604 2.9e-07
SEG 238-256 ,577-582 ,623-638 ,718-753
Function
Function in SwissProt
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).