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IID50225
 UniprotQ07794
ProteinHistone acetyltransferase RTT109
GeneRTT109
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
436
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-127,171-403 Hetero dimer :
 Evidence X-RAY 3cz7 A Reference
       Region 3cz7 A 1-127 order
       Region 3cz7 A 171-403 order
Seq 1-436 Hetero tetramer : IID50212Complex
 Evidence X-RAY 3q35 A Reference
       Region 3q35 A 1-129 order
       Region 3q35 A 130-133 disorder
       Region 3q35 A 134-165 order
       Region 3q35 A 166-171 disorder
       Region 3q35 A 172-404 order
       Region 3q35 A 405-436 disorder
Seq 1-436 Monomer :
 Evidence X-RAY 3qm0 A Reference
       Region 3qm0 A 1-129 order
       Region 3qm0 A 180-404 order
       Region 3qm0 A 405-436 disorder
 Evidence X-RAY 2rim A Reference
       Region 2rim A 1-142 order
       Region 2rim A 143-174 disorder
       Region 2rim A 175-404 order
       Region 2rim A 405-436 disorder
 Evidence X-RAY 2zfn A Reference
       Region 2zfn A 1-142 order
       Region 2zfn A 143-174 disorder
       Region 2zfn A 175-404 order
       Region 2zfn A 405-436 disorder
Seq 1-436 Hetero trimer : IID50212Complex
 Evidence X-RAY 3q68 C Reference
       Region 3q68 C 1-403 order
       Region 3q68 C 404-436 disorder
 Evidence X-RAY 3q66 C Reference
       Region 3q66 C 1-426 order
       Region 3q66 C 427-436 disorder
Seq 1-436 Hetero hexamer : IID50143Complex,IID50212Complex
 Evidence X-RAY 3q33 A Reference
       Region 3q33 A 1-129 order
       Region 3q33 A 130-133 disorder
       Region 3q33 A 134-165 order
       Region 3q33 A 166-171 disorder
       Region 3q33 A 172-404 order
       Region 3q33 A 405-436 disorder
Seq 419-433 Hetero dimer : IID50170Complex
 Evidence NMR 6f0y B Reference
       Region 6f0y B 419-433 order
       Region 6f0y B 419-419 high_rmsd
       Region 6f0y B 431-433 high_rmsd
SeqProS verified 144-155 Hetero hexamer : IID50143Complex,IID50212Complex
       Region 3q33 A 134-165 order
       Region 2rim A 143-174 disorder
SeqProS verified 144-155 Hetero trimer : IID50212Complex
       Region 3q66 C 1-426 order
       Region 2rim A 143-174 disorder
Seqacetylation
    290-290 N6-acetyllysine; by autocatalysis
 
Prediction
NeProc
Disorder 338-351,401-436
Order 1-37,42-124,135-140,145-177,184-337,356-400
AlphaFold
Disorder 161-172,322-323,405-436
Order 1-160,173-321,324-404
SEG 424-435
Function
Function in SwissProt
Histone chaperone-dependent acetylase that modifies 'Lys-9', 'Lys-14', 'Lys-23', 'Lys-27', and 'Lys-56' on histone H3 (H3K9Ac, H3K14Ac and H3K23Ac, H3K27Ac, and H3K56Ac) to promote nucleosome assembly, genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:31194870, PubMed:17046836, PubMed:17369253, PubMed:17320445, PubMed:17272723, PubMed:18723682, PubMed:20560668, PubMed:21256037, PubMed:29300933, PubMed:19172748, PubMed:19683497). Its residue selectivity is influenced by the acetylation status of histone H3, and also the presence of histone chaperone ASF1 that shifts selectivity to 'Lys-56' when H3K14Ac is already present (PubMed:31194870). H3K56 acetylation weakens the interaction between the histone core and the surrounding DNA in the nucleosomal particle and drives chromatin disassembly (PubMed:18577595). Autoacetylates (PubMed:18568037, PubMed:18707894, PubMed:18719104). Independently of acetyltransferase activity, stimulates histone deposition by VPS75 (PubMed:19172748). Involved in regulation of Ty1 transposition (PubMed:11779788).