Search Keyword:


Search option:


IID50271
UniprotP20676
ProteinNucleoporin NUP1
GeneNUP1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1076
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1076 Hetero dimer : IID50327Complex
 Evidence X-RAY 5owu B Reference
       Region 5owu B 1-973 disorder
       Region 5owu B 974-988 order
       Region 5owu B 989-998 disorder
       Region 5owu B 999-1012 order
       Region 5owu B 1013-1076 disorder
Seq 316-340 Hetero octamer : IID50280Complex,IID50337Complex,P06704
 Evidence X-RAY 4mbe Y Reference
       Region 4mbe Y 316-326 disorder
       Region 4mbe Y 327-330 order
       Region 4mbe Y 331-340 disorder
 Evidence X-RAY 4mbe X Reference
       Region 4mbe X 316-324 disorder
       Region 4mbe X 325-330 order
       Region 4mbe X 331-340 disorder
 Evidence X-RAY 4mbe H Reference
       Region 4mbe H 316-329 disorder
       Region 4mbe H 330-339 order
       Region 4mbe H 340-340 disorder
 Evidence X-RAY 4mbe G Reference
       Region 4mbe G 316-330 disorder
       Region 4mbe G 331-339 order
       Region 4mbe G 340-340 disorder
Seq 322-355 Hetero hexamer : IID50280Complex,IID50337Complex
 Evidence X-RAY 4c31 Y Reference
       Region 4c31 Y 322-325 disorder
       Region 4c31 Y 326-331 order
       Region 4c31 Y 332-355 disorder
 Evidence X-RAY 4c31 X Reference
       Region 4c31 X 322-326 disorder
       Region 4c31 X 327-331 order
       Region 4c31 X 332-355 disorder
 Evidence X-RAY 4c31 F Reference
       Region 4c31 F 322-326 disorder
       Region 4c31 F 327-340 order
       Region 4c31 F 341-355 disorder
 Evidence X-RAY 4c31 C Reference
       Region 4c31 C 322-325 disorder
       Region 4c31 C 326-340 order
       Region 4c31 C 341-355 disorder
SeqProS verified 327-331 Hetero hexamer : IID50280Complex,IID50337Complex
       Region 4c31 C 326-340 order
       Region 4c31 F 327-340 order
       Region 4c31 X 327-331 order
       Region 4c31 Y 326-331 order
       Region 5owu B 1-973 disorder
SeqProS verified 327-339 Hetero octamer : IID50280Complex,IID50337Complex,P06704
       Region 4mbe X 325-330 order
       Region 4mbe Y 327-330 order
       Region 4mbe G 331-339 order
       Region 4mbe H 330-339 order
       Region 5owu B 1-973 disorder
Seqphosphorylation
    161-161 Phosphoserine
    54-54 Phosphoserine
    637-637 Phosphoserine
    381-381 Phosphothreonine
    383-383 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-78,123-1076
Order 79-122
ProS 5-11,16-40,48-78,123-130
AlphaFold
Disorder 1-18,21-21,28-99,126-276,290-1076
Order 19-20,22-27,100-125,277-289
SEG 2-11 ,97-113 ,344-357 ,454-465 ,591-603 ,708-723 ,800-823 ,826-840 ,861-894 ,965-981 ,1046-1065
Function
Function in SwissProt
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). As one of the FG repeat nucleoporins NUP1 is involved in interactions with and guidance of nuclear transport receptors such as SRP1-KAP95 (importin alpha and beta) through the NPC. Like the closely related NUP2 it also plays an important role in disassembling and recycling SRP1-KAP95 to the cytoplasm after nuclear import. Upon entry of the heterotrimeric SRP1-KAP95-cargo complex in the nucleus, NUP1 binds through its C-terminus to KAP95, thus accelerating the release of KAP95 and, indirectly, of the nuclear localization signal (NLS)-containing cargo from the SRP1-KAP95-cargo complex.