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IID50280
 UniprotP46674
ProteinNuclear mRNA export protein SAC3
GeneSAC3
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1301
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1301 Hetero trimer : Q08231
 Evidence X-RAY 5l3t A Reference
       Region 5l3t A 1-253 disorder
       Region 5l3t A 254-547 order
       Region 5l3t A 548-1301 disorder
 Evidence X-RAY 3t5v D Reference
       Region 3t5v D 250-251 disorder
       Region 3t5v D 252-550 order
       Region 3t5v D 551-563 disorder
Seq 250-563 Hetero trimer : O94742,Q08231
 Evidence X-RAY 3t5v A Reference
       Region 3t5v A 250-252 disorder
       Region 3t5v A 253-551 order
       Region 3t5v A 552-563 disorder
Seq 253-551 Hetero hexamer : Q08231
 Evidence X-RAY 4trq D Reference
       Region 4trq D 253-551 order
 Evidence X-RAY 4trq A Reference
       Region 4trq A 253-551 order
Seq 723-805 Hetero tetramer : IID50337Complex,P06704
 Evidence X-RAY 3fwc F Reference
       Region 3fwc F 723-805 order
 Evidence X-RAY 3fwc N Reference
       Region 3fwc N 723-805 order
Seq 723-805 Hetero tetramer : IID50337Complex,P06704
 Evidence X-RAY 3fwc B Reference
       Region 3fwc B 723-804 order
       Region 3fwc B 805-805 disorder
 Evidence X-RAY 3fwc J Reference
       Region 3fwc J 723-727 disorder
       Region 3fwc J 728-805 order
Seq 752-805 Hetero trimer : IID50337Complex,P06704
 Evidence X-RAY 3fwb B Reference
       Region 3fwb B 752-805 order
Seq 753-805 Hetero octamer : IID50271Complex,IID50337Complex,P06704
 Evidence X-RAY 4mbe E Reference
       Region 4mbe E 753-754 disorder
       Region 4mbe E 755-805 order
 Evidence X-RAY 4mbe B Reference
       Region 4mbe B 753-755 disorder
       Region 4mbe B 756-805 order
Seq 757-787 Hetero hexamer : IID50271Complex,IID50337Complex
 Evidence X-RAY 4c31 D Reference
       Region 4c31 D 757-786 order
       Region 4c31 D 787-787 disorder
 Evidence X-RAY 4c31 A Reference
       Region 4c31 A 757-786 order
       Region 4c31 A 787-787 disorder
Seqphosphorylation
    866-866 Phosphoserine
    568-568 Phosphoserine
Seqacetylation
    748-748 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-139,559-684,732-737,815-870,1090-1100,1129-1133,1146-1301
Order 140-558,685-731,738-814,871-1089,1101-1128,1134-1145
ProS 37-41,137-139,732-737,815-834,847-870,1090-1099,1129-1133,1146-1174,1184-1194,1200-1206,1212-1219,1238-1253,1260-1262,1279-1301
AlphaFold
Disorder 1-99,102-102,113-113,123-125,553-697,699-699,831-870,872-884,906-906,979-979,1056-1057,1090-1110,1127-1138,1144-1284,1287-1287,1298-1301
Order 100-101,103-112,114-122,126-552,698-698,700-830,871-871,885-905,907-978,980-1055,1058-1089,1111-1126,1139-1143,1285-1286,1288-1297
Pfam Hmmer
PF03399 248-483 1.3e-95
SEG 22-36 ,241-252 ,314-321 ,695-719 ,810-825 ,944-955 ,1113-1124 ,1175-1186
Function
Function in SwissProt
Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket.