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IID50311
 UniprotP19619
ProteinAnnexin A1
GeneANXA1
OrganismSus scrofa
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
346
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-346 Monomer :
 Evidence X-RAY 1hm6 A Reference
       Region 1hm6 A 1-1 disorder
       Region 1hm6 A 2-344 order
       Region 1hm6 A 345-346 disorder
 Evidence X-RAY 1hm6 B Reference
       Region 1hm6 B 1-1 disorder
       Region 1hm6 B 2-344 order
       Region 1hm6 B 345-346 disorder
 Evidence X-RAY 1mcx A Reference
       Region 1mcx A 1-40 disorder
       Region 1mcx A 41-344 order
       Region 1mcx A 345-346 disorder
SeqProS verified 2-40 :
       Region 1hm6 A 2-344 order
       Region 1hm6 B 2-344 order
       Region 1mcx A 1-40 disorder
Seqphosphorylation
    37-37 Phosphoserine
    41-41 Phosphothreonine
    136-136 Phosphothreonine
    21-21 Phosphotyrosine; by EGFR
    34-34 Phosphoserine
    5-5 Phosphoserine; by TRPM7
Seqacetylation
    312-312 N6-acetyllysine
    239-239 N6-acetyllysine
    58-58 N6-acetyllysine
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 16-30
Order 1-15,31-346
ProS 16-21
AlphaFold
Disorder 1-1,247-247,249-249
Order 2-246,248-248,250-346
Pfam Hmmer
PF00191 46-111 1.7e-21
PF00191 118-183 1.3e-32
PF00191 201-267 4.7e-20
PF00191 277-342 3.7e-32
Function
Function in SwissProt
Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2.
Biological Process
Diagram with PDB data
ANXA1X-RAY STRUCTURE OF FULL-LENGTH ANNEXIN 1