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IID50332
 UniprotQ61496
ProteinATP-dependent RNA helicase DDX4
GeneDdx4
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
702
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 201-220 Hetero tetramer : IID00733Complex
 Evidence X-RAY 5jiu D Reference
       Region 5jiu D 201-207 disorder
       Region 5jiu D 208-213 order
       Region 5jiu D 214-220 disorder
 Evidence X-RAY 5jiu C Reference
       Region 5jiu C 201-207 disorder
       Region 5jiu C 208-213 order
       Region 5jiu C 214-220 disorder
SeqProS predicted 208-213 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, FolderIndex, MobiDB). Hetero tetramer : IID00733Complex
       Region 5jiu C 208-213 order
       Region 5jiu D 208-213 order
Seqphosphorylation
    700-700 Phosphoserine
    199-199 Phosphoserine
    195-195 Phosphoserine
 
Prediction
NeProc
Disorder 1-225,652-702
Order 226-328,334-651
ProS 1-11,17-225,665-686,698-702
AlphaFold
Disorder 1-215,234-238,329-333,482-482,573-574,576-576,578-578,651-672,674-702
Order 216-233,239-328,334-481,483-572,575-575,577-577,579-650,673-673
Pfam Hmmer
PF00270 285-464 6.7e-70
PF00271 532-608 2.9e-35
SEG 58-76 ,118-139 ,175-183 ,221-229
Function
Function in SwissProt
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20439430, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20439430, PubMed:28633017). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (PubMed:20439430, PubMed:28633017). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (PubMed:28633017).