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IID50340
 UniprotQ80V62
ProteinFanconi anemia group D2 protein homolog
GeneFancd2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1450
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 33-850,911-1415 Hetero dimer : IID50341Complex
 Evidence X-RAY 3s4w B Reference
       Region 3s4w B 33-42 disorder
       Region 3s4w B 43-117 order
       Region 3s4w B 118-127 disorder
       Region 3s4w B 128-306 order
       Region 3s4w B 307-334 disorder
       Region 3s4w B 335-585 order
       Region 3s4w B 586-601 disorder
       Region 3s4w B 602-707 order
       Region 3s4w B 708-722 disorder
       Region 3s4w B 723-845 order
       Region 3s4w B 846-850 disorder
       Region 3s4w B 911-913 disorder
       Region 3s4w B 914-940 order
       Region 3s4w B 941-957 disorder
       Region 3s4w B 958-979 order
       Region 3s4w B 980-998 disorder
       Region 3s4w B 999-1035 order
       Region 3s4w B 1036-1048 disorder
       Region 3s4w B 1049-1143 order
       Region 3s4w B 1144-1147 disorder
       Region 3s4w B 1148-1166 order
       Region 3s4w B 1167-1171 disorder
       Region 3s4w B 1172-1213 order
       Region 3s4w B 1214-1217 disorder
       Region 3s4w B 1218-1247 order
       Region 3s4w B 1248-1251 disorder
       Region 3s4w B 1252-1391 order
       Region 3s4w B 1392-1415 disorder
Seqphosphorylation
    220-220 Phosphoserine
    714-714 Phosphoserine
    1255-1255 Phosphoserine
    1404-1404 Phosphoserine
    1412-1412 Phosphoserine
    1426-1426 Phosphothreonine
    1434-1434 Phosphoserine
 
Prediction
NeProc
Disorder 1-41,318-333,589-598,709-722,847-911,979-992,1250-1256,1394-1450
Order 42-317,334-588,599-708,723-846,912-941,948-978,993-1095,1102-1249,1257-1393
ProS 318-333,718-722,847-847,907-911,987-992,1394-1400
AlphaFold
Disorder 1-43,119-129,165-165,305-337,541-546,587-601,686-691,707-722,765-768,837-915,937-956,980-997,1036-1049,1098-1101,1146-1147,1166-1172,1215-1215,1250-1250,1378-1389,1392-1395,1397-1450
Order 44-118,130-164,166-304,338-540,547-586,602-685,692-706,723-764,769-836,916-936,957-979,998-1035,1050-1097,1102-1145,1148-1165,1173-1214,1216-1249,1251-1377,1390-1391,1396-1396
SEG 315-331 ,591-602 ,714-729 ,856-872 ,1130-1140 ,1323-1339 ,1401-1414 ,1430-1450
Function
Function in SwissProt
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Biological Process
See also
Diagram with PDB data
Fanci/Fancd2Structure of the FANCI-FANCD2 complex