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IID50344
 UniprotG1K2L5
ProteinCellular tumor antigen p53
Genetp53
OrganismDanio rerio
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
374
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 302-346 Homo tetramer :
 Evidence X-RAY 4d1l C Reference
       Region 4d1l C 302-340 order
       Region 4d1l C 341-346 disorder
 Evidence X-RAY 4d1l D Reference
       Region 4d1l D 302-342 order
       Region 4d1l D 343-346 disorder
 Evidence X-RAY 4d1l E Reference
       Region 4d1l E 302-302 disorder
       Region 4d1l E 303-343 order
       Region 4d1l E 344-346 disorder
 Evidence X-RAY 4d1l F Reference
       Region 4d1l F 302-339 order
       Region 4d1l F 340-346 disorder
 Evidence X-RAY 4d1m A Reference
       Region 4d1m A 302-302 disorder
       Region 4d1m A 303-340 order
       Region 4d1m A 341-346 disorder
 Evidence X-RAY 4d1m B Reference
       Region 4d1m B 302-302 disorder
       Region 4d1m B 303-342 order
       Region 4d1m B 343-346 disorder
 Evidence X-RAY 4d1m C Reference
       Region 4d1m C 302-341 order
       Region 4d1m C 342-346 disorder
 Evidence X-RAY 4d1m D Reference
       Region 4d1m D 302-302 disorder
       Region 4d1m D 303-341 order
       Region 4d1m D 342-346 disorder
 Evidence X-RAY 4d1m I Reference
       Region 4d1m I 302-302 disorder
       Region 4d1m I 303-341 order
       Region 4d1m I 342-346 disorder
 Evidence X-RAY 4d1m J Reference
       Region 4d1m J 302-302 disorder
       Region 4d1m J 303-341 order
       Region 4d1m J 342-346 disorder
 Evidence X-RAY 4d1m K Reference
       Region 4d1m K 302-341 order
       Region 4d1m K 342-346 disorder
 Evidence X-RAY 4d1m L Reference
       Region 4d1m L 302-302 disorder
       Region 4d1m L 303-341 order
       Region 4d1m L 342-346 disorder
Seq 302-346 Homo tetramer :
 Evidence X-RAY 4d1l A Reference
       Region 4d1l A 302-302 disorder
       Region 4d1l A 303-340 order
       Region 4d1l A 341-346 disorder
 Evidence X-RAY 4d1l B Reference
       Region 4d1l B 302-302 disorder
       Region 4d1l B 303-339 order
       Region 4d1l B 340-346 disorder
 Evidence X-RAY 4d1m E Reference
       Region 4d1m E 302-302 disorder
       Region 4d1m E 303-344 order
       Region 4d1m E 345-346 disorder
 Evidence X-RAY 4d1m F Reference
       Region 4d1m F 302-302 disorder
       Region 4d1m F 303-343 order
       Region 4d1m F 344-346 disorder
 Evidence X-RAY 4d1m G Reference
       Region 4d1m G 302-340 order
       Region 4d1m G 341-346 disorder
 Evidence X-RAY 4d1m H Reference
       Region 4d1m H 302-302 disorder
       Region 4d1m H 303-342 order
       Region 4d1m H 343-346 disorder
 
Prediction
NeProc
Disorder 1-64,85-89,255-298,336-374
Order 65-84,90-120,125-254,299-335
ProS 6-16,44-50,255-260,336-342,360-374
AlphaFold
Disorder 1-63,266-301,344-344,346-374
Order 64-265,302-343,345-345
Pfam Hmmer
PF00870 64-258 5e-154
PF07710 293-336 1.2e-26
SEG 51-70 ,264-275
Function
Function in SwissProt
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.