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IID50346
UniprotO13024
ProteinInner centromere protein A
Geneincenp-a
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
873
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 790-847 Hetero dimer : IID50395Complex
 Evidence X-RAY 4b8l D Reference
       Region 4b8l D 797-838 order
       Region 4b8l D 839-840 disorder
 Evidence X-RAY 4b8m D Reference
       Region 4b8m D 797-797 disorder
       Region 4b8m D 798-840 order
 Evidence X-RAY 4b8m C Reference
       Region 4b8m C 797-837 order
       Region 4b8m C 838-840 disorder
 Evidence X-RAY 2bfx D Reference
       Region 2bfx D 798-840 order
 Evidence X-RAY 2bfx C Reference
       Region 2bfx C 798-837 order
       Region 2bfx C 838-840 disorder
 Evidence X-RAY 2bfy D Reference
       Region 2bfy D 798-804 disorder
       Region 2bfy D 805-837 order
       Region 2bfy D 838-840 disorder
 Evidence X-RAY 2bfy C Reference
       Region 2bfy C 798-799 disorder
       Region 2bfy C 800-837 order
       Region 2bfy C 838-840 disorder
 Evidence X-RAY 4c2v D Reference
       Region 4c2v D 797-797 disorder
       Region 4c2v D 798-840 order
 Evidence X-RAY 4c2v C Reference
       Region 4c2v C 797-837 order
       Region 4c2v C 838-840 disorder
 Evidence X-RAY 4c2w D Reference
       Region 4c2w D 797-797 disorder
       Region 4c2w D 798-847 order
 Evidence X-RAY 4c2w C Reference
       Region 4c2w C 797-797 disorder
       Region 4c2w C 798-837 order
       Region 4c2w C 838-847 disorder
 Evidence X-RAY 5eyk C Reference
       Region 5eyk C 790-802 disorder
       Region 5eyk C 803-837 order
       Region 5eyk C 838-847 disorder
 Evidence X-RAY 2vgp D Reference
       Region 2vgp D 798-840 order
 Evidence X-RAY 2vgp C Reference
       Region 2vgp C 798-837 order
       Region 2vgp C 838-840 disorder
 Evidence X-RAY 2vrx D Reference
       Region 2vrx D 798-840 order
 Evidence X-RAY 2vrx C Reference
       Region 2vrx C 798-837 order
       Region 2vrx C 838-840 disorder
 Evidence X-RAY 3ztx D Reference
       Region 3ztx D 797-797 disorder
       Region 3ztx D 798-840 order
 Evidence X-RAY 3ztx C Reference
       Region 3ztx C 797-797 disorder
       Region 3ztx C 798-837 order
       Region 3ztx C 838-840 disorder
Seq 790-847 Hetero tetramer : IID50395Complex
 Evidence X-RAY 2vgo D Reference
       Region 2vgo D 797-797 disorder
       Region 2vgo D 798-840 order
 Evidence X-RAY 2vgo C Reference
       Region 2vgo C 797-837 order
       Region 2vgo C 838-840 disorder
 Evidence X-RAY 5k3y D Reference
       Region 5k3y D 790-804 disorder
       Region 5k3y D 805-840 order
       Region 5k3y D 841-847 disorder
 Evidence X-RAY 5k3y C Reference
       Region 5k3y C 790-802 disorder
       Region 5k3y C 803-837 order
       Region 5k3y C 838-847 disorder
Seq 790-847 Hetero dimer : IID50395Complex
 Evidence X-RAY 5eyk D Reference
       Region 5eyk D 790-804 disorder
       Region 5eyk D 805-826 order
       Region 5eyk D 827-847 disorder
Seqphosphorylation
    849-849 Phosphoserine
    850-850 Phosphoserine
 
Prediction
NeProc
Disorder 1-5,48-494,742-790,842-873
Order 6-47,495-741,791-841
ProS 48-62,68-76,152-172,260-266,318-325,412-413,454-460,479-491,742-750,756-761,773-790,842-858,866-873
AlphaFold
Disorder 1-1,45-54,56-158,170-283,313-496,614-614,715-715,718-788,847-873
Order 2-44,55-55,159-169,284-312,497-613,615-714,716-717,789-846
Pfam Hmmer
PF03941 781-839 1.5e-34
SEG 85-105 ,255-287 ,314-325 ,416-451 ,524-544 ,550-563 ,580-605 ,615-639 ,641-677 ,680-741
Function
Function in SwissProt
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.
Biological Process
See also
Diagram with PDB data
aurkb-a/incenp-aMechanism of Aurora-B activation by INCENP and inhibition by Hesperadin.