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IID50349
UniprotO70201
ProteinBaculoviral IAP repeat-containing protein 5
GeneBirc5
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
140
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-140 Monomer :
 Evidence X-RAY 1m4m A Reference
       Region 1m4m A 1-6 disorder
       Region 1m4m A 7-118 order
       Region 1m4m A 119-140 disorder
Seqphosphorylation
    34-34 Phosphothreonine; by CDK1 and CDK15
    48-48 Phosphothreonine
    117-117 Phosphothreonine; by AURKB
Seqacetylation
    23-23 N6-acetyllysine
    90-90 N6-acetyllysine
    110-110 N6-acetyllysine
    115-115 N6-acetyllysine
    112-112 N6-acetyllysine
    129-129 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-7,134-140
Order 8-133
ProS 4-7,134-140
AlphaFold
Disorder 1-4
Order 5-140
Pfam Hmmer
PF00653 18-88 6.2e-34
Function
Function in SwissProt
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:25778398). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (By similarity). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (By similarity). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (By similarity). May counteract a default induction of apoptosis in G2/M phase (By similarity). The acetylated form represses STAT3 transactivation of target gene promoters (By similarity). May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity). Essential for the maintenance of mitochondrial integrity and function (PubMed:25778398).