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IID50352
 UniprotP06786
ProteinDNA topoisomerase 2
GeneTOP2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1428
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-413 Homo dimer :
 Evidence X-RAY 1qzr B Reference
       Region 1qzr B 1-7 disorder
       Region 1qzr B 8-260 order
       Region 1qzr B 261-275 disorder
       Region 1qzr B 276-334 order
       Region 1qzr B 335-339 disorder
       Region 1qzr B 340-405 order
       Region 1qzr B 406-413 disorder
 Evidence X-RAY 1qzr A Reference
       Region 1qzr A 1-6 disorder
       Region 1qzr A 7-258 order
       Region 1qzr A 259-275 disorder
       Region 1qzr A 276-334 order
       Region 1qzr A 335-339 disorder
       Region 1qzr A 340-410 order
       Region 1qzr A 411-413 disorder
 Evidence X-RAY 1pvg B Reference
       Region 1pvg B 1-7 disorder
       Region 1pvg B 8-259 order
       Region 1pvg B 260-275 disorder
       Region 1pvg B 276-334 order
       Region 1pvg B 335-338 disorder
       Region 1pvg B 339-405 order
       Region 1pvg B 406-413 disorder
 Evidence X-RAY 1pvg A Reference
       Region 1pvg A 1-6 disorder
       Region 1pvg A 7-258 order
       Region 1pvg A 259-275 disorder
       Region 1pvg A 276-334 order
       Region 1pvg A 335-339 disorder
       Region 1pvg A 340-406 order
       Region 1pvg A 407-413 disorder
Seq 1-1177 Homo dimer :
 Evidence X-RAY 4gfh F Reference
       Region 4gfh F 1-6 disorder
       Region 4gfh F 7-258 order
       Region 4gfh F 259-275 disorder
       Region 4gfh F 276-404 order
       Region 4gfh F 405-420 disorder
       Region 4gfh F 421-602 order
       Region 4gfh F 603-606 disorder
       Region 4gfh F 607-1070 order
       Region 4gfh F 1071-1106 disorder
       Region 4gfh F 1107-1177 order
 Evidence X-RAY 4gfh A Reference
       Region 4gfh A 1-6 disorder
       Region 4gfh A 7-258 order
       Region 4gfh A 259-275 disorder
       Region 4gfh A 276-408 order
       Region 4gfh A 409-420 disorder
       Region 4gfh A 421-602 order
       Region 4gfh A 603-606 disorder
       Region 4gfh A 607-1070 order
       Region 4gfh A 1071-1106 disorder
       Region 4gfh A 1107-1177 order
Seq 409-1201 Homo dimer :
 Evidence X-RAY 1bgw A Reference
       Region 1bgw A 409-418 disorder
       Region 1bgw A 419-632 order
       Region 1bgw A 633-681 disorder
       Region 1bgw A 682-1075 order
       Region 1bgw A 1076-1106 disorder
       Region 1bgw A 1107-1177 order
       Region 1bgw A 1178-1201 disorder
 Evidence X-RAY 1bjt A Reference
       Region 1bjt A 409-418 disorder
       Region 1bjt A 419-484 order
       Region 1bjt A 485-489 disorder
       Region 1bjt A 490-526 order
       Region 1bjt A 527-531 disorder
       Region 1bjt A 532-631 order
       Region 1bjt A 632-652 disorder
       Region 1bjt A 653-659 order
       Region 1bjt A 660-674 disorder
       Region 1bjt A 675-1071 order
       Region 1bjt A 1072-1106 disorder
       Region 1bjt A 1107-1178 order
       Region 1bjt A 1179-1201 disorder
 Evidence X-RAY 2rgr A Reference
       Region 2rgr A 419-1070 order
       Region 2rgr A 1071-1108 disorder
       Region 2rgr A 1109-1177 order
Seq 421-1177 Monomer :
 Evidence X-RAY 3l4j A Reference
       Region 3l4j A 421-1070 order
       Region 3l4j A 1071-1106 disorder
       Region 3l4j A 1107-1177 order
 Evidence X-RAY 3l4k A Reference
       Region 3l4k A 421-1070 order
       Region 3l4k A 1071-1106 disorder
       Region 3l4k A 1107-1177 order
SeqProS verified 335-338,633-681 DNA binding Homo dimer :
       Region 4gfh A 276-408 order
       Region 4gfh F 276-404 order
       Region 4gfh A 607-1070 order
       Region 4gfh F 607-1070 order
       Region 1pvg B 335-338 disorder
       Region 1bgw A 633-681 disorder
SeqProS verified 633-681 DNA binding Homo dimer :
       Region 2rgr A 419-1070 order
       Region 1bgw A 633-681 disorder
SeqProS verified 633-681 DNA binding :
       Region 3l4k A 421-1070 order
       Region 3l4j A 421-1070 order
       Region 1bgw A 633-681 disorder
Seqphosphorylation
    1423-1423 Phosphoserine; by CK2
    1408-1408 Phosphoserine; by CK2
    1356-1356 Phosphoserine; by CK2
    1353-1353 Phosphoserine; by CK2
    1272-1272 Phosphoserine; by CK2
    1266-1266 Phosphoserine; by CK2
    1269-1269 Phosphoserine; by CK2
    1258-1258 Phosphothreonine; by CK2
    1252-1252 Phosphoserine
    1087-1087 Phosphoserine; by CK2
    1086-1086 Phosphothreonine; by CK2
 
Prediction
NeProc
Disorder 1-9,262-268,417-419,1067-1109,1174-1428
Order 10-261,276-416,420-1066,1110-1173
ProS 9-9,417-419,1067-1070,1174-1180
AlphaFold
Disorder 1-6,129-130,141-141,262-278,336-338,939-939,1073-1109,1178-1225,1234-1428
Order 7-128,131-140,142-261,279-335,339-938,940-1072,1110-1177,1226-1233
Pfam Hmmer
PF02518 55-204 1.4e-15
PF00204 250-418 2.3e-48
PF00521 690-1171 3.4e-105
SEG 326-346 ,452-465 ,1086-1100 ,1126-1149 ,1184-1195 ,1266-1272 ,1321-1345 ,1380-1392 ,1402-1416
Function
Function in SwissProt
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.