SeqProS possible 33-38 The corresponding residues of human c-Myc (P01106) is disordered in the free state (PMID:22457068); The N- and C-termini of MB0 show no NOEs to any PAD residues, and are more disordered than MYC-V19QPYFY24 in all 20 structures of the ensemble (PMID:35244724). These residues correspond to 33-38 in P09416-1; Note: the sequence of c-Myc in 7LQT matches the human c-Myc (P01106).
Hetero dimer : IID50266Complex
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes (PubMed:17304222). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (By similarity). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).