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IID50355
UniprotP09416
ProteinMyc proto-oncogene protein
GeneMyc
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
453
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-44 Hetero dimer : IID50266Complex
 Evidence NMR 7lqt A 7lqt-A chain is a fusion protein composed of Ppp1r10 and c-Myc. Reference
       Region 7lqt A 27-44 order
       Region 7lqt A 27-27 high_rmsd
       Region 7lqt A 40-44 high_rmsd
SeqProS possible 33-38 The corresponding residues of human c-Myc (P01106) is disordered in the free state (PMID:22457068); The N- and C-termini of MB0 show no NOEs to any PAD residues, and are more disordered than MYC-V19QPYFY24 in all 20 structures of the ensemble (PMID:35244724). These residues correspond to 33-38 in P09416-1; Note: the sequence of c-Myc in 7LQT matches the human c-Myc (P01106). Hetero dimer : IID50266Complex
       Region 7lqt A 27-44 order
Seqphosphorylation
    20-20 Phosphoserine
    76-76 Phosphoserine; by DYRK2
    72-72 Phosphothreonine; by GSK3; alternate
    85-85 Phosphoserine
    176-176 Phosphoserine
    307-307 Phosphoserine
    343-343 Phosphoserine; by PIM2; in vitro
Seqacetylation
    163-163 N6-acetyllysine; alternate
    158-158 N6-acetyllysine; by PCAF; alternate
    172-172 N6-acetyllysine; by PCAF
    289-289 N6-acetyllysine; by PCAF
    331-331 N6-acetyllysine; by PCAF
    337-337 N6-acetyllysine; by PCAF
    385-385 N6-acetyllysine; by PCAF
 
Prediction
NeProc
Disorder 1-27,35-40,48-374,452-453
Order 28-34,41-47,375-451
ProS 1-8,24-27,35-40,62-72,96-159,192-196,202-217,245-257,273-283,290-293,326-329,346-359,365-374,452-453
AlphaFold
Disorder 1-48,50-61,64-97,99-151,153-187,196-196,198-260,262-262,265-307,312-349,439-439
Order 49-49,62-63,98-98,152-152,188-195,197-197,261-261,263-264,308-311,350-438
Pfam Hmmer
PF01056 15-359 3.3e-204
PF00010 369-421 7.3e-19
PF02344 422-453 1.9e-17
SEG 69-87 ,217-244 ,256-282 ,289-308
Function
Function in SwissProt
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes (PubMed:17304222). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (By similarity). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity).