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IID50358
 UniprotP17785
ProteinAnnexin A2
GeneANXA2
OrganismGallus gallus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
339
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 2-14 Hetero tetramer : IID00813Complex
 Evidence X-RAY 1bt6 D Reference
       Region 1bt6 D 2-12 order
       Region 1bt6 D 13-14 disorder
 Evidence X-RAY 1bt6 C Reference
       Region 1bt6 C 2-12 order
       Region 1bt6 C 13-14 disorder
SeqProS possible 2-12 Same region of the human homolog (P07355, 90% identity) is disordered in the free state. Hetero tetramer : IID00813Complex
       Region 1bt6 C 2-12 order
       Region 1bt6 D 2-12 order
Seqphosphorylation
    26-26 Phosphothreonine; by PKC
    24-24 Phosphotyrosine; by SRC
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-21
Order 22-339
ProS 1-15
AlphaFold
Disorder 1-2,5-21
Order 3-4,22-339
Pfam Hmmer
PF00191 37-102 5.5e-26
PF00191 109-174 2.8e-35
PF00191 193-259 8.2e-20
PF00191 269-334 2.8e-28
SEG 34-45
Function
Function in SwissProt
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity.
Biological Process
See also
Diagram with PDB data
ANXA2/S100A10P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS
AHNAK/ANXA2/S100A10The crystal structure of an AHNAK peptide in complex with the S100A10/AnxA2 heterotetramer
HLTF/S100A10/ANXA2Crystal Structure of p11-Annexin A2(N-terminal) Fusion Protein in Complex with SMARCA3 Peptide