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IID50360
 UniprotP20067
ProteinDNA-binding protein inhibitor ID-1
GeneId1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
168
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 52-104 Homo dimer :
 Evidence X-RAY 6u2u B Reference
       Region 6u2u B 59-102 order
       Region 6u2u B 103-104 disorder
 Evidence X-RAY 6u2u A Reference
       Region 6u2u A 59-104 order
 Evidence X-RAY 6mgm B Reference
       Region 6mgm B 52-54 disorder
       Region 6mgm B 55-104 order
 Evidence X-RAY 6mgm A Reference
       Region 6mgm A 52-60 disorder
       Region 6mgm A 61-104 order
Seq 58-104 Hetero dimer : IID00541Complex
 Evidence X-RAY 6mgn B Reference
       Region 6mgn B 58-104 order
 
Prediction
NeProc
Disorder 1-54,106-157,163-168
Order 55-105,158-162
ProS 26-42,48-54,121-133,144-150,163-168
AlphaFold
Disorder 1-56,58-58,60-60,105-123,133-168
Order 57-57,59-59,61-104,124-132
Pfam Hmmer
PF00010 44-99 4.7e-10
SEG 4-13
Function
Function in SwissProt
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.