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IID50362
 UniprotP25604
ProteinSuppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease
GeneSTP22
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
385
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-160 Hetero dimer : IID50368Complex
 Evidence X-RAY 3r42 A Reference
       Region 3r42 A 1-4 disorder
       Region 3r42 A 5-160 order
Seq 1-160 Monomer :
 Evidence X-RAY 3r3q A Reference
       Region 3r3q A 1-7 disorder
       Region 3r3q A 8-160 order
Seq 1-161 Hetero dimer : P0CH28
 Evidence X-RAY 1uzx A Reference
       Region 1uzx A 1-7 disorder
       Region 1uzx A 8-72 order
       Region 1uzx A 73-79 disorder
       Region 1uzx A 80-109 order
       Region 1uzx A 110-113 disorder
       Region 1uzx A 114-158 order
       Region 1uzx A 159-161 disorder
Seq 215-385 Hetero tetramer : IID50369Complex,IID50383Complex,IID50403Complex
 Evidence X-RAY 2p22 A Reference
       Region 2p22 A 215-217 disorder
       Region 2p22 A 218-385 order
Seq 305-385 Hetero trimer : IID50383Complex,IID50403Complex
 Evidence X-RAY 2caz A Reference
       Region 2caz A 305-324 disorder
       Region 2caz A 325-382 order
       Region 2caz A 383-385 disorder
 Evidence X-RAY 2caz D Reference
       Region 2caz D 305-324 disorder
       Region 2caz D 325-384 order
       Region 2caz D 385-385 disorder
 Evidence X-RAY 2f66 A Reference
       Region 2f66 A 322-385 order
 Evidence X-RAY 2f66 D Reference
       Region 2f66 D 322-385 order
Seq 322-385 Hetero dimer : IID50383Complex
 Evidence X-RAY 2f6m A Reference
       Region 2f6m A 322-385 order
 Evidence X-RAY 2f6m C Reference
       Region 2f6m C 322-383 order
       Region 2f6m C 384-385 disorder
 
Prediction
NeProc
Disorder 1-9,166-253
Order 10-165,254-385
ProS 179-186,196-210,229-253
AlphaFold
Disorder 1-6,72-77,154-221,307-311,385-385
Order 7-71,78-153,222-306,312-384
Pfam Hmmer
PF05743 31-162 1.4e-54
SEG 178-201
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association to the ESCRT-0 complex. Required for vacuolar targeting of temperature-sensitive plasma membrane proteins STE2 and CAN1.
Biological Process
Diagram with PDB data
STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment