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IID50363
 UniprotP25644
ProteinDNA topoisomerase 2-associated protein PAT1
GenePAT1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
796
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 5-79 Hetero dimer : P39517
 Evidence X-RAY 4brw B Reference
       Region 4brw B 5-24 disorder
       Region 4brw B 25-54 order
       Region 4brw B 55-79 disorder
Seq 422-796 Hetero decamer : P38203,P57743
 Evidence X-RAY 4n0a J Reference
       Region 4n0a J 422-469 disorder
       Region 4n0a J 470-750 order
       Region 4n0a J 751-757 disorder
       Region 4n0a J 758-794 order
       Region 4n0a J 795-796 disorder
 Evidence X-RAY 4n0a I Reference
       Region 4n0a I 422-469 disorder
       Region 4n0a I 470-750 order
       Region 4n0a I 751-757 disorder
       Region 4n0a I 758-793 order
       Region 4n0a I 794-796 disorder
 Evidence X-RAY 4n0a H Reference
       Region 4n0a H 422-469 disorder
       Region 4n0a H 470-750 order
       Region 4n0a H 751-757 disorder
       Region 4n0a H 758-794 order
       Region 4n0a H 795-796 disorder
Seq 435-796 Hetero tetramer : P53550
 Evidence X-RAY 5lm5 B Reference
       Region 5lm5 B 435-467 disorder
       Region 5lm5 B 468-600 order
       Region 5lm5 B 601-603 disorder
       Region 5lm5 B 604-647 order
       Region 5lm5 B 648-658 disorder
       Region 5lm5 B 659-796 order
 Evidence X-RAY 5lm5 A Reference
       Region 5lm5 A 435-467 disorder
       Region 5lm5 A 468-644 order
       Region 5lm5 A 645-657 disorder
       Region 5lm5 A 658-795 order
       Region 5lm5 A 796-796 disorder
Seq 435-796 Hetero dimer : P53550
 Evidence X-RAY 5lmg A Reference
       Region 5lmg A 435-467 disorder
       Region 5lmg A 468-645 order
       Region 5lmg A 646-658 disorder
       Region 5lmg A 659-796 order
 Evidence X-RAY 5lmg B Reference
       Region 5lmg B 435-472 disorder
       Region 5lmg B 473-517 order
       Region 5lmg B 518-520 disorder
       Region 5lmg B 521-796 order
Seq 435-796 Hetero dimer : P53550
 Evidence X-RAY 5lmf A Reference
       Region 5lmf A 435-471 disorder
       Region 5lmf A 472-646 order
       Region 5lmf A 647-659 disorder
       Region 5lmf A 660-796 order
 Evidence X-RAY 5lmf B Reference
       Region 5lmf B 435-472 disorder
       Region 5lmf B 473-599 order
       Region 5lmf B 600-603 disorder
       Region 5lmf B 604-653 order
       Region 5lmf B 654-655 disorder
       Region 5lmf B 656-796 order
Seq 456-783 Hetero octamer : P38203,P57743
 Evidence X-RAY 4c8q H Reference
       Region 4c8q H 456-470 disorder
       Region 4c8q H 471-648 order
       Region 4c8q H 649-655 disorder
       Region 4c8q H 656-695 order
       Region 4c8q H 696-698 disorder
       Region 4c8q H 699-713 order
       Region 4c8q H 714-715 disorder
       Region 4c8q H 716-742 order
       Region 4c8q H 743-764 disorder
       Region 4c8q H 765-783 order
Seq 473-796 Monomer :
 Evidence X-RAY 4ogp A Reference
       Region 4ogp A 473-473 disorder
       Region 4ogp A 474-644 order
       Region 4ogp A 645-653 disorder
       Region 4ogp A 654-796 order
 Evidence X-RAY 4ogp B Reference
       Region 4ogp B 473-648 order
       Region 4ogp B 649-653 disorder
       Region 4ogp B 654-796 order
 Evidence X-RAY 4ojj C Reference
       Region 4ojj C 473-475 disorder
       Region 4ojj C 476-796 order
 Evidence X-RAY 4ojj A Reference
       Region 4ojj A 473-473 disorder
       Region 4ojj A 474-787 order
       Region 4ojj A 788-796 disorder
 Evidence X-RAY 4ojj B Reference
       Region 4ojj B 473-479 disorder
       Region 4ojj B 480-489 order
       Region 4ojj B 490-522 disorder
       Region 4ojj B 523-694 order
       Region 4ojj B 695-699 disorder
       Region 4ojj B 700-795 order
       Region 4ojj B 796-796 disorder
Seqphosphorylation
    456-456 Phosphoserine
    457-457 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-275,315-472,744-748
Order 276-314,473-573,580-648,654-688,696-743,756-796
ProS 1-57,108-112,261-275,326-372,387-412
AlphaFold
Disorder 1-34,36-36,38-38,41-254,276-276,294-305,308-308,312-350,353-353,357-357,361-361,363-473
Order 35-35,37-37,39-40,255-275,277-293,306-307,309-311,351-352,354-356,358-360,362-362,474-796
SEG 59-74 ,111-137 ,149-157 ,165-183 ,187-224 ,404-415 ,434-450 ,545-555 ,571-583
Function
Function in SwissProt
Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. First decay factor recruited to mRNA, at a time when the mRNA is still associated with translation factors. Subsequently, PAT1 recruits the hepta-heterodimer LSM1-LSM7 complex to P-bodies. In association with the LSM1-LSM7 complex, stabilizes the 3' terminus of mRNAs. This association is also required for mosaic virus genomic RNA translation. Modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Required for 40S ribosomal subunit joining to capped and/or polyadenylated mRNA. With other P-body components, enhances the formation of retrotransposition-competent Ty1 virus-like particles. Necessary for accurate chromosome transmission during cell division.