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IID50366
 UniprotP38753
ProteinClass E vacuolar protein-sorting machinery protein HSE1
GeneHSE1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
452
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 288-375 Hetero dimer : IID50368Complex
 Evidence X-RAY 2pjw H Reference
       Region 2pjw H 288-375 order
 
Prediction
NeProc
Disorder 1-6,154-167,196-215,272-292,313-319,373-452
Order 7-147,168-195,216-271,293-312,320-372
ProS 154-160,272-276,313-319,447-452
AlphaFold
Disorder 1-1,146-163,185-219,276-277,377-452
Order 2-145,164-184,220-275,278-376
Pfam Hmmer
PF00790 2-141 1.5e-58
PF00018 220-274 7.3e-25
SEG 179-190 ,197-207 ,276-289
Function
Function in SwissProt
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Biological Process
See also
Diagram with PDB data
STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
VPS27/HSE1The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment