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IID50369
 UniprotP42939
ProteinMultivesicular body sorting factor 12
GeneMVB12
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
101
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-81 Hetero tetramer : IID50362Complex,IID50383Complex,IID50403Complex
 Evidence X-RAY 2p22 D Reference
       Region 2p22 D 4-81 order
 
Prediction
NeProc
Disorder 1-3,93-101
Order 4-92
ProS 93-98
AlphaFold
Disorder 1-2,82-101
Order 3-81
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Appears to be involved in cargo sorting and release of the ESCRT-I complex from the MVBs.
Biological Process
See also
Diagram with PDB data
STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment