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IID50371
 UniprotP47142
ProteinVacuolar protein-sorting-associated protein 25
GeneVPS25
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
202
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-202 Homo dimer :
 Evidence X-RAY 1xb4 D Reference
       Region 1xb4 D 1-1 disorder
       Region 1xb4 D 2-18 order
       Region 1xb4 D 19-21 disorder
       Region 1xb4 D 22-54 order
       Region 1xb4 D 55-73 disorder
       Region 1xb4 D 74-106 order
       Region 1xb4 D 107-120 disorder
       Region 1xb4 D 121-139 order
       Region 1xb4 D 140-142 disorder
       Region 1xb4 D 143-155 order
       Region 1xb4 D 156-160 disorder
       Region 1xb4 D 161-184 order
       Region 1xb4 D 185-186 disorder
       Region 1xb4 D 187-201 order
       Region 1xb4 D 202-202 disorder
 Evidence X-RAY 1xb4 C Reference
       Region 1xb4 C 1-2 disorder
       Region 1xb4 C 3-56 order
       Region 1xb4 C 57-72 disorder
       Region 1xb4 C 73-155 order
       Region 1xb4 C 156-158 disorder
       Region 1xb4 C 159-201 order
       Region 1xb4 C 202-202 disorder
 Evidence X-RAY 1xb4 B Reference
       Region 1xb4 B 1-52 order
       Region 1xb4 B 53-73 disorder
       Region 1xb4 B 74-156 order
       Region 1xb4 B 157-158 disorder
       Region 1xb4 B 159-202 order
 Evidence X-RAY 1xb4 A Reference
       Region 1xb4 A 1-55 order
       Region 1xb4 A 56-72 disorder
       Region 1xb4 A 73-113 order
       Region 1xb4 A 114-115 disorder
       Region 1xb4 A 116-155 order
       Region 1xb4 A 156-157 disorder
       Region 1xb4 A 158-201 order
       Region 1xb4 A 202-202 disorder
Seq 1-202 Hetero tetramer : IID50387Complex,IID50389Complex
 Evidence X-RAY 1w7p C Reference
       Region 1w7p C 1-54 order
       Region 1w7p C 55-71 disorder
       Region 1w7p C 72-199 order
       Region 1w7p C 200-202 disorder
 Evidence X-RAY 1w7p B Reference
       Region 1w7p B 1-54 order
       Region 1w7p B 55-71 disorder
       Region 1w7p B 72-199 order
       Region 1w7p B 200-202 disorder
 Evidence X-RAY 1u5t D Reference
       Region 1u5t D 1-1 disorder
       Region 1u5t D 2-51 order
       Region 1u5t D 52-71 disorder
       Region 1u5t D 72-199 order
       Region 1u5t D 200-202 disorder
 Evidence X-RAY 1u5t C Reference
       Region 1u5t C 1-1 disorder
       Region 1u5t C 2-51 order
       Region 1u5t C 52-71 disorder
       Region 1u5t C 72-199 order
       Region 1u5t C 200-202 disorder
 
Prediction
NeProc
Disorder 58-68
Order 1-51,70-202
ProS 58-59
AlphaFold
Disorder 1-2,55-71,115-117
Order 3-54,72-114,118-202
Pfam Hmmer
PF05871 2-202 7.9e-130
SEG 109-120
Function
Function in SwissProt
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
Biological Process
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment