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IID50372
 UniprotP52917
ProteinVacuolar protein sorting-associated protein 4
GeneVPS4
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
437
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-82 Hetero dimer : IID50385Complex
 Evidence X-RAY 5fvl A Reference
       Region 5fvl A 1-82 order
 Evidence X-RAY 5fvl B Reference
       Region 5fvl B 1-3 disorder
       Region 5fvl B 4-81 order
       Region 5fvl B 82-82 disorder
Seq 1-82 Hetero dimer : IID50365Complex
 Evidence X-RAY 2v6x A Reference
       Region 2v6x A 1-80 order
       Region 2v6x A 81-82 disorder
Seq 1-82 Hetero dimer : P40080
 Evidence X-RAY 5fvk A Reference
       Region 5fvk A 1-82 order
 Evidence X-RAY 5fvk B Reference
       Region 5fvk B 1-82 order
 Evidence X-RAY 4niq A Reference
       Region 4niq A 1-82 order
 Evidence X-RAY 4niq B Reference
       Region 4niq B 1-3 disorder
       Region 4niq B 4-81 order
       Region 4niq B 82-82 disorder
Seq 83-437 Homo trimer :
 Evidence X-RAY 2qpa C Reference
       Region 2qpa C 83-122 disorder
       Region 2qpa C 123-238 order
       Region 2qpa C 239-247 disorder
       Region 2qpa C 248-263 order
       Region 2qpa C 264-268 disorder
       Region 2qpa C 269-432 order
       Region 2qpa C 433-437 disorder
 Evidence X-RAY 2qpa B Reference
       Region 2qpa B 83-118 disorder
       Region 2qpa B 119-238 order
       Region 2qpa B 239-247 disorder
       Region 2qpa B 248-263 order
       Region 2qpa B 264-268 disorder
       Region 2qpa B 269-435 order
       Region 2qpa B 436-437 disorder
 Evidence X-RAY 2qpa A Reference
       Region 2qpa A 83-118 disorder
       Region 2qpa A 119-238 order
       Region 2qpa A 239-247 disorder
       Region 2qpa A 248-263 order
       Region 2qpa A 264-266 disorder
       Region 2qpa A 267-435 order
       Region 2qpa A 436-437 disorder
Seq 83-437 Monomer :
 Evidence X-RAY 3eie A Reference
       Region 3eie A 122-240 order
       Region 3eie A 241-246 disorder
       Region 3eie A 247-364 order
       Region 3eie A 365-368 disorder
       Region 3eie A 369-433 order
       Region 3eie A 434-437 disorder
 Evidence X-RAY 3eih A Reference
       Region 3eih A 104-118 disorder
       Region 3eih A 119-437 order
 Evidence X-RAY 3eih B Reference
       Region 3eih B 104-119 disorder
       Region 3eih B 120-435 order
       Region 3eih B 436-437 disorder
 Evidence X-RAY 3eih C Reference
       Region 3eih C 104-122 disorder
       Region 3eih C 123-239 order
       Region 3eih C 240-244 disorder
       Region 3eih C 245-437 order
 Evidence X-RAY 2qp9 X Reference
       Region 2qp9 X 83-128 disorder
       Region 2qp9 X 129-206 order
       Region 2qp9 X 207-209 disorder
       Region 2qp9 X 210-239 order
       Region 2qp9 X 240-245 disorder
       Region 2qp9 X 246-264 order
       Region 2qp9 X 265-267 disorder
       Region 2qp9 X 268-365 order
       Region 2qp9 X 366-370 disorder
       Region 2qp9 X 371-433 order
       Region 2qp9 X 434-437 disorder
Seq 124-437 Homo dimer :
 Evidence X-RAY 2rko A Reference
       Region 2rko A 124-128 disorder
       Region 2rko A 129-204 order
       Region 2rko A 205-207 disorder
       Region 2rko A 208-238 order
       Region 2rko A 239-247 disorder
       Region 2rko A 248-263 order
       Region 2rko A 264-267 disorder
       Region 2rko A 268-363 order
       Region 2rko A 364-372 disorder
       Region 2rko A 373-433 order
       Region 2rko A 434-437 disorder
Seq 299-413 Hetero tetramer : IID50386Complex
 Evidence X-RAY 3mhv C Reference
       Region 3mhv C 299-364 order
       Region 3mhv C 365-368 disorder
       Region 3mhv C 369-387 order
       Region 3mhv C 388-398 disorder
       Region 3mhv C 399-413 order
 
Prediction
NeProc
Disorder 1-1,85-109,431-437
Order 2-84,110-430
ProS 431-437
AlphaFold
Disorder 1-3,81-110,121-125,240-244,263-267,435-437
Order 4-80,111-120,126-239,245-262,268-434
Pfam Hmmer
PF04212 44-72 2.5e-12
PF00004 168-352 1.1e-80
SEG 22-34 ,79-98 ,102-112
Function
Function in SwissProt
Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex.
Biological Process
Diagram with PDB data
VPS4/VTA1/DID4Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p