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IID50373
 UniprotP53762
ProteinAryl hydrocarbon receptor nuclear translocator
GeneArnt
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
791
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 81-231,257-464 Hetero dimer : IID50388Complex
 Evidence X-RAY 7v7w A Reference
       Region 7v7w A 81-98 disorder
       Region 7v7w A 99-118 order
       Region 7v7w A 119-125 disorder
       Region 7v7w A 126-142 order
       Region 7v7w A 143-155 disorder
       Region 7v7w A 156-231 order
       Region 7v7w A 257-273 order
       Region 7v7w A 274-299 disorder
       Region 7v7w A 300-316 order
       Region 7v7w A 317-332 disorder
       Region 7v7w A 333-464 order
 Evidence X-RAY 7v7l A Reference
       Region 7v7l A 81-97 disorder
       Region 7v7l A 98-118 order
       Region 7v7l A 119-125 disorder
       Region 7v7l A 126-142 order
       Region 7v7l A 143-155 disorder
       Region 7v7l A 156-231 order
       Region 7v7l A 257-273 order
       Region 7v7l A 274-299 disorder
       Region 7v7l A 300-316 order
       Region 7v7l A 317-330 disorder
       Region 7v7l A 331-349 order
       Region 7v7l A 350-351 disorder
       Region 7v7l A 352-464 order
Seq 81-464 Hetero dimer : IID50381Complex
 Evidence X-RAY 4zp4 A Reference
       Region 4zp4 A 82-97 disorder
       Region 4zp4 A 98-142 order
       Region 4zp4 A 143-158 disorder
       Region 4zp4 A 159-228 order
       Region 4zp4 A 229-258 disorder
       Region 4zp4 A 259-271 order
       Region 4zp4 A 272-300 disorder
       Region 4zp4 A 301-315 order
       Region 4zp4 A 316-333 disorder
       Region 4zp4 A 334-346 order
       Region 4zp4 A 347-359 disorder
       Region 4zp4 A 360-464 order
 Evidence X-RAY 4zp4 C Reference
       Region 4zp4 C 82-97 disorder
       Region 4zp4 C 98-142 order
       Region 4zp4 C 143-160 disorder
       Region 4zp4 C 161-228 order
       Region 4zp4 C 229-258 disorder
       Region 4zp4 C 259-270 order
       Region 4zp4 C 271-300 disorder
       Region 4zp4 C 301-315 order
       Region 4zp4 C 316-333 disorder
       Region 4zp4 C 334-347 order
       Region 4zp4 C 348-360 disorder
       Region 4zp4 C 361-464 order
 Evidence X-RAY 4zph A Reference
       Region 4zph A 82-97 disorder
       Region 4zph A 98-142 order
       Region 4zph A 143-159 disorder
       Region 4zph A 160-227 order
       Region 4zph A 228-258 disorder
       Region 4zph A 259-269 order
       Region 4zph A 270-300 disorder
       Region 4zph A 301-314 order
       Region 4zph A 315-334 disorder
       Region 4zph A 335-345 order
       Region 4zph A 346-359 disorder
       Region 4zph A 360-464 order
 Evidence X-RAY 4zph C Reference
       Region 4zph C 82-97 disorder
       Region 4zph C 98-141 order
       Region 4zph C 142-159 disorder
       Region 4zph C 160-227 order
       Region 4zph C 228-258 disorder
       Region 4zph C 259-269 order
       Region 4zph C 270-300 disorder
       Region 4zph C 301-314 order
       Region 4zph C 315-334 disorder
       Region 4zph C 335-344 order
       Region 4zph C 345-359 disorder
       Region 4zph C 360-464 order
 Evidence X-RAY 4zpk A Reference
       Region 4zpk A 82-86 disorder
       Region 4zpk A 87-142 order
       Region 4zpk A 143-156 disorder
       Region 4zpk A 157-227 order
       Region 4zpk A 228-258 disorder
       Region 4zpk A 259-271 order
       Region 4zpk A 272-300 disorder
       Region 4zpk A 301-313 order
       Region 4zpk A 314-334 disorder
       Region 4zpk A 335-345 order
       Region 4zpk A 346-360 disorder
       Region 4zpk A 361-464 order
 Evidence X-RAY 4zqd A Reference
       Region 4zqd A 82-99 disorder
       Region 4zqd A 100-121 order
       Region 4zqd A 122-127 disorder
       Region 4zqd A 128-142 order
       Region 4zqd A 143-159 disorder
       Region 4zqd A 160-225 order
       Region 4zqd A 226-258 disorder
       Region 4zqd A 259-269 order
       Region 4zqd A 270-300 disorder
       Region 4zqd A 301-314 order
       Region 4zqd A 315-334 disorder
       Region 4zqd A 335-345 order
       Region 4zqd A 346-360 disorder
       Region 4zqd A 361-464 order
 Evidence X-RAY 4zqd C Reference
       Region 4zqd C 82-97 disorder
       Region 4zqd C 98-141 order
       Region 4zqd C 142-159 disorder
       Region 4zqd C 160-227 order
       Region 4zqd C 228-258 disorder
       Region 4zqd C 259-269 order
       Region 4zqd C 270-300 disorder
       Region 4zqd C 301-315 order
       Region 4zqd C 316-334 disorder
       Region 4zqd C 335-344 order
       Region 4zqd C 345-360 disorder
       Region 4zqd C 361-464 order
 Evidence X-RAY 6e3s A Reference
       Region 6e3s A 81-97 disorder
       Region 6e3s A 98-119 order
       Region 6e3s A 120-125 disorder
       Region 6e3s A 126-142 order
       Region 6e3s A 143-158 disorder
       Region 6e3s A 159-227 order
       Region 6e3s A 228-258 disorder
       Region 6e3s A 259-271 order
       Region 6e3s A 272-300 disorder
       Region 6e3s A 301-315 order
       Region 6e3s A 316-334 disorder
       Region 6e3s A 335-344 order
       Region 6e3s A 345-360 disorder
       Region 6e3s A 361-464 order
 Evidence X-RAY 6e3t A Reference
       Region 6e3t A 81-102 disorder
       Region 6e3t A 103-142 order
       Region 6e3t A 143-162 disorder
       Region 6e3t A 163-204 order
       Region 6e3t A 205-206 disorder
       Region 6e3t A 207-225 order
       Region 6e3t A 226-258 disorder
       Region 6e3t A 259-271 order
       Region 6e3t A 272-300 disorder
       Region 6e3t A 301-315 order
       Region 6e3t A 316-333 disorder
       Region 6e3t A 334-346 order
       Region 6e3t A 347-360 disorder
       Region 6e3t A 361-463 order
       Region 6e3t A 464-464 disorder
 Evidence X-RAY 6e3u A Reference
       Region 6e3u A 81-99 disorder
       Region 6e3u A 100-118 order
       Region 6e3u A 119-126 disorder
       Region 6e3u A 127-142 order
       Region 6e3u A 143-158 disorder
       Region 6e3u A 159-227 order
       Region 6e3u A 228-258 disorder
       Region 6e3u A 259-270 order
       Region 6e3u A 271-300 disorder
       Region 6e3u A 301-315 order
       Region 6e3u A 316-333 disorder
       Region 6e3u A 334-355 order
       Region 6e3u A 356-359 disorder
       Region 6e3u A 360-464 order
 Evidence X-RAY 7w80 A Reference
       Region 7w80 A 81-100 disorder
       Region 7w80 A 101-142 order
       Region 7w80 A 143-157 disorder
       Region 7w80 A 158-230 order
       Region 7w80 A 231-256 disorder
       Region 7w80 A 257-270 order
       Region 7w80 A 271-301 disorder
       Region 7w80 A 302-316 order
       Region 7w80 A 317-333 disorder
       Region 7w80 A 334-345 order
       Region 7w80 A 346-359 disorder
       Region 7w80 A 360-464 order
Seq 82-360 Hetero dimer : Q8BGD7
 Evidence X-RAY 7xhv A Reference
       Region 7xhv A 82-84 disorder
       Region 7xhv A 85-121 order
       Region 7xhv A 122-122 disorder
       Region 7xhv A 123-144 order
       Region 7xhv A 145-155 disorder
       Region 7xhv A 156-228 order
       Region 7xhv A 229-257 disorder
       Region 7xhv A 258-274 order
       Region 7xhv A 275-302 disorder
       Region 7xhv A 303-319 order
       Region 7xhv A 320-334 disorder
       Region 7xhv A 335-345 order
       Region 7xhv A 346-360 disorder
Seq 82-464 Hetero dimer : Q8BGD7
 Evidence X-RAY 7xi4 A Reference
       Region 7xi4 A 82-147 order
       Region 7xi4 A 148-154 disorder
       Region 7xi4 A 155-228 order
       Region 7xi4 A 229-257 disorder
       Region 7xi4 A 258-273 order
       Region 7xi4 A 274-302 disorder
       Region 7xi4 A 303-314 order
       Region 7xi4 A 315-334 disorder
       Region 7xi4 A 335-345 order
       Region 7xi4 A 346-360 disorder
       Region 7xi4 A 361-464 order
Seq 82-464 Hetero dimer : IID50405Complex
 Evidence X-RAY 5sy7 A Reference
       Region 5sy7 A 82-88 disorder
       Region 5sy7 A 89-142 order
       Region 5sy7 A 143-155 disorder
       Region 5sy7 A 156-228 order
       Region 5sy7 A 229-258 disorder
       Region 5sy7 A 259-271 order
       Region 5sy7 A 272-290 disorder
       Region 5sy7 A 291-311 order
       Region 5sy7 A 312-336 disorder
       Region 5sy7 A 337-349 order
       Region 5sy7 A 350-361 disorder
       Region 5sy7 A 362-463 order
       Region 5sy7 A 464-464 disorder
Seq 82-464 Hetero dimer : IID50379Complex
 Evidence X-RAY 5sy5 A Reference
       Region 5sy5 A 82-98 disorder
       Region 5sy5 A 99-142 order
       Region 5sy5 A 143-155 disorder
       Region 5sy5 A 156-227 order
       Region 5sy5 A 228-254 disorder
       Region 5sy5 A 255-271 order
       Region 5sy5 A 272-289 disorder
       Region 5sy5 A 290-315 order
       Region 5sy5 A 316-334 disorder
       Region 5sy5 A 335-349 order
       Region 5sy5 A 350-360 disorder
       Region 5sy5 A 361-464 order
 Evidence X-RAY 5sy5 C Reference
       Region 5sy5 C 82-102 disorder
       Region 5sy5 C 103-142 order
       Region 5sy5 C 143-156 disorder
       Region 5sy5 C 157-226 order
       Region 5sy5 C 227-257 disorder
       Region 5sy5 C 258-271 order
       Region 5sy5 C 272-289 disorder
       Region 5sy5 C 290-294 order
       Region 5sy5 C 295-295 disorder
       Region 5sy5 C 296-315 order
       Region 5sy5 C 316-334 disorder
       Region 5sy5 C 335-349 order
       Region 5sy5 C 350-359 disorder
       Region 5sy5 C 360-464 order
 Evidence X-RAY 5sy5 E Reference
       Region 5sy5 E 82-97 disorder
       Region 5sy5 E 98-143 order
       Region 5sy5 E 144-152 disorder
       Region 5sy5 E 153-226 order
       Region 5sy5 E 227-254 disorder
       Region 5sy5 E 255-269 order
       Region 5sy5 E 270-289 disorder
       Region 5sy5 E 290-296 order
       Region 5sy5 E 297-298 disorder
       Region 5sy5 E 299-315 order
       Region 5sy5 E 316-334 disorder
       Region 5sy5 E 335-349 order
       Region 5sy5 E 350-359 disorder
       Region 5sy5 E 360-464 order
Seq 82-464 Hetero dimer : IID50330Complex
 Evidence X-RAY 4zpr A Reference
       Region 4zpr A 82-86 disorder
       Region 4zpr A 87-118 order
       Region 4zpr A 119-120 disorder
       Region 4zpr A 121-142 order
       Region 4zpr A 143-159 disorder
       Region 4zpr A 160-180 order
       Region 4zpr A 181-183 disorder
       Region 4zpr A 184-226 order
       Region 4zpr A 227-259 disorder
       Region 4zpr A 260-269 order
       Region 4zpr A 270-305 disorder
       Region 4zpr A 306-311 order
       Region 4zpr A 312-337 disorder
       Region 4zpr A 338-344 order
       Region 4zpr A 345-360 disorder
       Region 4zpr A 361-427 order
       Region 4zpr A 428-437 disorder
       Region 4zpr A 438-464 order
Seq 84-273,302-345 Hetero dimer : IID00799Complex
 Evidence X-RAY 5nj8 B Reference
       Region 5nj8 B 84-84 disorder
       Region 5nj8 B 85-119 order
       Region 5nj8 B 120-125 disorder
       Region 5nj8 B 126-143 order
       Region 5nj8 B 144-151 disorder
       Region 5nj8 B 152-228 order
       Region 5nj8 B 229-258 disorder
       Region 5nj8 B 259-269 order
       Region 5nj8 B 270-273 disorder
       Region 5nj8 B 302-316 order
       Region 5nj8 B 317-323 disorder
       Region 5nj8 B 324-329 order
       Region 5nj8 B 330-333 disorder
       Region 5nj8 B 334-345 order
Seq 84-273,302-345 Hetero dimer : IID00799Complex
 Evidence X-RAY 5nj8 D Reference
       Region 5nj8 D 84-144 order
       Region 5nj8 D 145-147 disorder
       Region 5nj8 D 148-173 order
       Region 5nj8 D 174-174 disorder
       Region 5nj8 D 175-177 order
       Region 5nj8 D 178-187 disorder
       Region 5nj8 D 188-196 order
       Region 5nj8 D 197-198 disorder
       Region 5nj8 D 199-203 order
       Region 5nj8 D 204-206 disorder
       Region 5nj8 D 207-211 order
       Region 5nj8 D 212-258 disorder
       Region 5nj8 D 259-269 order
       Region 5nj8 D 270-273 disorder
       Region 5nj8 D 302-306 disorder
       Region 5nj8 D 307-314 order
       Region 5nj8 D 315-336 disorder
       Region 5nj8 D 337-342 order
       Region 5nj8 D 343-345 disorder
Seq 358-466 Hetero tetramer : E1JIM6
 Evidence X-RAY 7vni D Reference
       Region 7vni D 358-360 disorder
       Region 7vni D 361-464 order
       Region 7vni D 465-466 disorder
 Evidence X-RAY 7vni C Reference
       Region 7vni C 358-361 disorder
       Region 7vni C 362-464 order
       Region 7vni C 465-466 disorder
SeqProS verified 82-97 interact with DNA Hetero dimer : Q8BGD7
       Region 7xhv A 85-121 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 82-97 interact with DNA Hetero dimer : Q8BGD7
       Region 7xi4 A 82-147 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 84-97 interact with DNA Hetero dimer : IID00799Complex
       Region 5nj8 B 85-119 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 84-97 interact with DNA Hetero dimer : IID00799Complex
       Region 5nj8 D 84-144 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 87-97 interact with DNA Hetero dimer : IID50330Complex
       Region 4zpr A 87-118 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 87-97 interact with DNA Hetero dimer : IID50381Complex
       Region 4zpk A 87-142 order
       Region 4zp4 A 82-97 disorder
SeqProS verified 89-97 interact with DNA Hetero dimer : IID50405Complex
       Region 5sy7 A 89-142 order
       Region 4zp4 A 82-97 disorder
Seqphosphorylation
    77-77 Phosphoserine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-102,234-297,318-332,469-791
Order 103-227,298-317,333-468
ProS 7-14,59-64,72-79,87-102,234-247,254-274,282-297,329-332,624-627,760-765,773-791
AlphaFold
Disorder 1-83,143-157,227-238,240-258,271-300,315-333,345-360,466-791
Order 84-142,158-226,239-239,259-270,301-314,334-344,361-465
Pfam Hmmer
PF00010 90-143 1e-16
PF00989 163-270 1.1e-19
PF08447 373-467 8.9e-24
SEG 24-34 ,251-262 ,725-738
Function
Function in SwissProt
Required for activity of the AHR. Upon ligand binding, AHR translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE). Not required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex initiates transcription of genes involved in the regulation of a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (PubMed:26245371, PubMed:27782878). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820, PubMed:26245371, PubMed:27782878).
Biological Process
Diagram with PDB data
Arnt/Epas1/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA
See also
Diagram with PDB data
Epas1/Arnt/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA