Search Keyword:


Search option:


IID50374
 UniprotP53843
ProteinVacuolar protein sorting-associated protein IST1
GeneIST1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
298
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-193 Monomer :
 Evidence X-RAY 3ggy A Reference
       Region 3ggy A 1-5 disorder
       Region 3ggy A 6-191 order
       Region 3ggy A 192-193 disorder
 Evidence X-RAY 3ggy B Reference
       Region 3ggy B 1-5 disorder
       Region 3ggy B 6-191 order
       Region 3ggy B 192-193 disorder
Seq 1-193 Hetero dimer : IID50377Complex
 Evidence X-RAY 3ggz A Reference
       Region 3ggz A 1-2 disorder
       Region 3ggz A 3-188 order
       Region 3ggz A 189-193 disorder
 Evidence X-RAY 3ggz B Reference
       Region 3ggz B 1-4 disorder
       Region 3ggz B 5-190 order
       Region 3ggz B 191-193 disorder
 Evidence X-RAY 3ggz C Reference
       Region 3ggz C 1-4 disorder
       Region 3ggz C 5-186 order
       Region 3ggz C 187-193 disorder
 Evidence X-RAY 3ggz D Reference
       Region 3ggz D 1-4 disorder
       Region 3ggz D 5-192 order
       Region 3ggz D 193-193 disorder
 
Prediction
NeProc
Disorder 1-6,188-254
Order 7-90,98-187,255-298
ProS 201-205,245-253
AlphaFold
Disorder 1-4,188-243,245-282,297-298
Order 5-187,244-244,283-296
Pfam Hmmer
PF03398 18-147 1.5e-74
SEG 60-81 ,185-206 ,219-231 ,263-281
Function
Function in SwissProt
Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole. Regulates the recruitment of VPS4 to the ESCRT-III complex, probably in conjunction with DID2, and VPS4 catalyzes the disassembly of the ESCRT-III complex.