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IID50379
 UniprotP97459
ProteinNeuronal PAS domain-containing protein 1
GeneNpas1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
594
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 43-423 Hetero dimer : IID50373Complex
 Evidence X-RAY 5sy5 B Reference
       Region 5sy5 B 43-51 disorder
       Region 5sy5 B 52-109 order
       Region 5sy5 B 110-134 disorder
       Region 5sy5 B 135-200 order
       Region 5sy5 B 201-243 disorder
       Region 5sy5 B 244-256 order
       Region 5sy5 B 257-266 disorder
       Region 5sy5 B 267-279 order
       Region 5sy5 B 280-281 disorder
       Region 5sy5 B 282-292 order
       Region 5sy5 B 293-297 disorder
       Region 5sy5 B 298-388 order
       Region 5sy5 B 389-396 disorder
       Region 5sy5 B 397-422 order
       Region 5sy5 B 423-423 disorder
 Evidence X-RAY 5sy5 D Reference
       Region 5sy5 D 43-51 disorder
       Region 5sy5 D 52-109 order
       Region 5sy5 D 110-127 disorder
       Region 5sy5 D 128-200 order
       Region 5sy5 D 201-243 disorder
       Region 5sy5 D 244-256 order
       Region 5sy5 D 257-266 disorder
       Region 5sy5 D 267-279 order
       Region 5sy5 D 280-281 disorder
       Region 5sy5 D 282-292 order
       Region 5sy5 D 293-298 disorder
       Region 5sy5 D 299-388 order
       Region 5sy5 D 389-396 disorder
       Region 5sy5 D 397-421 order
       Region 5sy5 D 422-423 disorder
 Evidence X-RAY 5sy5 F Reference
       Region 5sy5 F 43-50 disorder
       Region 5sy5 F 51-109 order
       Region 5sy5 F 110-130 disorder
       Region 5sy5 F 131-200 order
       Region 5sy5 F 201-243 disorder
       Region 5sy5 F 244-256 order
       Region 5sy5 F 257-265 disorder
       Region 5sy5 F 266-279 order
       Region 5sy5 F 280-281 disorder
       Region 5sy5 F 282-292 order
       Region 5sy5 F 293-298 disorder
       Region 5sy5 F 299-388 order
       Region 5sy5 F 389-396 disorder
       Region 5sy5 F 397-421 order
       Region 5sy5 F 422-423 disorder
 
Prediction
NeProc
Disorder 1-56,112-135,203-246,423-556,561-594
Order 57-111,136-202,247-422,557-560
ProS 1-34,51-56,115-122,228-231,242-246,423-423,465-469,500-556,561-565,570-594
AlphaFold
Disorder 1-40,110-133,201-243,257-266,280-280,293-299,390-395,423-594
Order 41-109,134-200,244-256,267-279,281-292,300-389,396-422
Pfam Hmmer
PF00010 46-99 0.00091
PF00989 137-255 0.00089
PF08447 316-409 7.1e-14
SEG 7-23 ,109-128 ,212-223 ,275-288 ,291-301 ,428-443 ,478-489 ,574-587
Function
Function in SwissProt
May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878).