Search Keyword:


Search option:


IID50381
 UniprotP97481
ProteinEndothelial PAS domain-containing protein 1
GeneEpas1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
874
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 3-362 Hetero dimer : IID50373Complex
 Evidence X-RAY 4zp4 B Reference
       Region 4zp4 B 3-25 disorder
       Region 4zp4 B 26-75 order
       Region 4zp4 B 76-86 disorder
       Region 4zp4 B 87-149 order
       Region 4zp4 B 150-161 disorder
       Region 4zp4 B 162-201 order
       Region 4zp4 B 202-218 disorder
       Region 4zp4 B 219-360 order
       Region 4zp4 B 361-361 disorder
 Evidence X-RAY 4zp4 D Reference
       Region 4zp4 D 3-25 disorder
       Region 4zp4 D 26-73 order
       Region 4zp4 D 74-87 disorder
       Region 4zp4 D 88-149 order
       Region 4zp4 D 150-161 disorder
       Region 4zp4 D 162-176 order
       Region 4zp4 D 177-181 disorder
       Region 4zp4 D 182-202 order
       Region 4zp4 D 203-218 disorder
       Region 4zp4 D 219-360 order
       Region 4zp4 D 361-361 disorder
 Evidence X-RAY 4zph B Reference
       Region 4zph B 3-25 disorder
       Region 4zph B 26-75 order
       Region 4zph B 76-86 disorder
       Region 4zph B 87-149 order
       Region 4zph B 150-162 disorder
       Region 4zph B 163-176 order
       Region 4zph B 177-179 disorder
       Region 4zph B 180-201 order
       Region 4zph B 202-218 disorder
       Region 4zph B 219-361 order
 Evidence X-RAY 4zph D Reference
       Region 4zph D 3-24 disorder
       Region 4zph D 25-75 order
       Region 4zph D 76-86 disorder
       Region 4zph D 87-149 order
       Region 4zph D 150-161 disorder
       Region 4zph D 162-177 order
       Region 4zph D 178-179 disorder
       Region 4zph D 180-183 order
       Region 4zph D 184-184 disorder
       Region 4zph D 185-201 order
       Region 4zph D 202-218 disorder
       Region 4zph D 219-361 order
 Evidence X-RAY 4zpk B Reference
       Region 4zpk B 3-7 disorder
       Region 4zpk B 8-149 order
       Region 4zpk B 150-162 disorder
       Region 4zpk B 163-203 order
       Region 4zpk B 204-218 disorder
       Region 4zpk B 219-328 order
       Region 4zpk B 329-331 disorder
       Region 4zpk B 332-347 order
       Region 4zpk B 348-348 disorder
       Region 4zpk B 349-360 order
       Region 4zpk B 361-361 disorder
 Evidence X-RAY 4zqd B Reference
       Region 4zqd B 3-25 disorder
       Region 4zqd B 26-75 order
       Region 4zqd B 76-86 disorder
       Region 4zqd B 87-149 order
       Region 4zqd B 150-162 disorder
       Region 4zqd B 163-176 order
       Region 4zqd B 177-181 disorder
       Region 4zqd B 182-201 order
       Region 4zqd B 202-219 disorder
       Region 4zqd B 220-361 order
 Evidence X-RAY 4zqd D Reference
       Region 4zqd D 3-24 disorder
       Region 4zqd D 25-75 order
       Region 4zqd D 76-86 disorder
       Region 4zqd D 87-149 order
       Region 4zqd D 150-163 disorder
       Region 4zqd D 164-177 order
       Region 4zqd D 178-179 disorder
       Region 4zqd D 180-182 order
       Region 4zqd D 183-184 disorder
       Region 4zqd D 185-201 order
       Region 4zqd D 202-219 disorder
       Region 4zqd D 220-361 order
 Evidence X-RAY 6e3s B Reference
       Region 6e3s B 3-27 disorder
       Region 6e3s B 28-74 order
       Region 6e3s B 75-87 disorder
       Region 6e3s B 88-149 order
       Region 6e3s B 150-162 disorder
       Region 6e3s B 163-201 order
       Region 6e3s B 202-218 disorder
       Region 6e3s B 219-360 order
       Region 6e3s B 361-362 disorder
 Evidence X-RAY 6e3t B Reference
       Region 6e3t B 3-29 disorder
       Region 6e3t B 30-41 order
       Region 6e3t B 42-43 disorder
       Region 6e3t B 44-74 order
       Region 6e3t B 75-87 disorder
       Region 6e3t B 88-149 order
       Region 6e3t B 150-162 disorder
       Region 6e3t B 163-178 order
       Region 6e3t B 179-180 disorder
       Region 6e3t B 181-201 order
       Region 6e3t B 202-218 disorder
       Region 6e3t B 219-357 order
       Region 6e3t B 358-362 disorder
 Evidence X-RAY 6e3u B Reference
       Region 6e3u B 3-27 disorder
       Region 6e3u B 28-75 order
       Region 6e3u B 76-86 disorder
       Region 6e3u B 87-149 order
       Region 6e3u B 150-162 disorder
       Region 6e3u B 163-201 order
       Region 6e3u B 202-218 disorder
       Region 6e3u B 219-360 order
       Region 6e3u B 361-362 disorder
 Evidence X-RAY 7w80 B Reference
       Region 7w80 B 3-29 disorder
       Region 7w80 B 30-40 order
       Region 7w80 B 41-44 disorder
       Region 7w80 B 45-75 order
       Region 7w80 B 76-85 disorder
       Region 7w80 B 86-149 order
       Region 7w80 B 150-161 disorder
       Region 7w80 B 162-203 order
       Region 7w80 B 204-216 disorder
       Region 7w80 B 217-359 order
       Region 7w80 B 360-361 disorder
SeqProS verified 8-25 The alpha-1 helix in the bHLH domain extends in size to bind to DNA. Hetero dimer : IID50373Complex
       Region 4zpk B 8-149 order
       Region 4zp4 B 3-25 disorder
Seqphosphorylation
    844-844 Phosphothreonine
 
Prediction
NeProc
Disorder 1-25,79-85,151-162,207-211,356-831
Order 26-78,86-150,163-206,212-355,832-874
ProS 5-25,356-360,388-403,413-430,452-462,483-505,514-547,600-605,625-643,680-715,722-730,742-750,760-772,777-788,800-818,826-831
AlphaFold
Disorder 1-8,74-86,150-162,204-217,236-237,361-408,410-874
Order 9-73,87-149,163-203,218-235,238-360,409-409
Pfam Hmmer
PF08447 254-347 1.9e-26
SEG 5-20 ,464-484 ,725-737 ,775-796
Function
Function in SwissProt
Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:26245371). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
Biological Process
Diagram with PDB data
Epas1/Arnt/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA
See also
Diagram with PDB data
Arnt/Epas1/DNACrystal Structure of the Heterodimeric HIF-2a:ARNT Complex with HRE DNA