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IID50383
 UniprotQ02767
ProteinVacuolar protein sorting-associated protein 28
GeneVPS28
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
242
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-118 Hetero tetramer : IID50362Complex,IID50369Complex
 Evidence X-RAY 2p22 B Reference
       Region 2p22 B 1-6 disorder
       Region 2p22 B 7-89 order
       Region 2p22 B 90-108 disorder
       Region 2p22 B 109-117 order
       Region 2p22 B 118-118 disorder
Seq 1-147 Hetero trimer : IID50362Complex
 Evidence X-RAY 2caz B Reference
       Region 2caz B 1-22 disorder
       Region 2caz B 23-122 order
       Region 2caz B 123-147 disorder
 Evidence X-RAY 2caz E Reference
       Region 2caz E 1-21 disorder
       Region 2caz E 22-122 order
       Region 2caz E 123-147 disorder
 Evidence X-RAY 2f66 B Reference
       Region 2f66 B 13-14 disorder
       Region 2f66 B 15-125 order
 Evidence X-RAY 2f66 E Reference
       Region 2f66 E 13-14 disorder
       Region 2f66 E 15-125 order
Seq 13-118 Hetero dimer : IID50362Complex
 Evidence X-RAY 2f6m B Reference
       Region 2f6m B 13-118 order
 Evidence X-RAY 2f6m D Reference
       Region 2f6m D 13-15 disorder
       Region 2f6m D 16-117 order
       Region 2f6m D 118-118 disorder
Seq 148-242 Monomer :
 Evidence X-RAY 2g3k A Reference
       Region 2g3k A 148-241 order
 Evidence X-RAY 2g3k B Reference
       Region 2g3k B 148-241 order
 Evidence X-RAY 2g3k C Reference
       Region 2g3k C 148-241 order
 Evidence X-RAY 2g3k D Reference
       Region 2g3k D 148-241 order
 Evidence X-RAY 2g3k E Reference
       Region 2g3k E 148-241 order
 Evidence X-RAY 2g3k F Reference
       Region 2g3k F 148-241 order
 Evidence X-RAY 2g3k G Reference
       Region 2g3k G 148-241 order
 Evidence X-RAY 2j9v A Reference
       Region 2j9v A 148-242 order
Seq 148-242 Hetero dimer : IID50387Complex
 Evidence X-RAY 2j9u A Reference
       Region 2j9u A 148-241 order
       Region 2j9u A 242-242 disorder
 Evidence X-RAY 2j9u C Reference
       Region 2j9u C 148-241 order
       Region 2j9u C 242-242 disorder
 
Prediction
NeProc
Disorder 1-16,127-145
Order 17-126,146-242
ProS 5-9
AlphaFold
Disorder 1-13,126-146,214-214
Order 14-125,147-213,215-242
Pfam Hmmer
PF03997 40-242 1.7e-142
Function
Function in SwissProt
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole.
Biological Process
See also
Diagram with PDB data
STP22/VPS27Crystal structure of the yeast vps23 UEV domain in complex with a vps27 PSDP peptide
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment