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IID50386
 UniprotQ06263
ProteinVacuolar protein sorting-associated protein VTA1
GeneVTA1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
330
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-167 Hetero dimer :
 Evidence NMR 5h7p A Reference
       Region 5h7p A 1-167 order
Seq 1-167 Hetero dimer : IID50384Complex
 Evidence NMR 2luh A Reference
       Region 2luh A 1-167 order
Seq 1-167 Homo dimer :
 Evidence X-RAY 2rkk B Reference
       Region 2rkk B 1-64 order
       Region 2rkk B 65-75 disorder
       Region 2rkk B 76-167 order
 Evidence X-RAY 2rkk A Reference
       Region 2rkk A 1-64 order
       Region 2rkk A 65-75 disorder
       Region 2rkk A 76-167 order
Seq 280-330 Homo dimer :
 Evidence X-RAY 2rkl E Reference
       Region 2rkl E 280-285 disorder
       Region 2rkl E 286-329 order
       Region 2rkl E 330-330 disorder
 Evidence X-RAY 2rkl F Reference
       Region 2rkl F 280-330 order
 Evidence X-RAY 2rkl C Reference
       Region 2rkl C 280-330 order
 Evidence X-RAY 2rkl D Reference
       Region 2rkl D 280-288 disorder
       Region 2rkl D 289-330 order
 Evidence X-RAY 2rkl A Reference
       Region 2rkl A 280-330 order
 Evidence X-RAY 2rkl B Reference
       Region 2rkl B 280-280 disorder
       Region 2rkl B 281-330 order
Seq 289-330 Hetero tetramer : IID50372Complex
 Evidence X-RAY 3mhv A Reference
       Region 3mhv A 289-330 order
 
Prediction
NeProc
Disorder 168-233,262-284
Order 1-61,70-167,234-261,285-330
ProS 266-269
AlphaFold
Disorder 1-2,66-72,167-278,281-281
Order 3-65,73-166,279-280,282-330
SEG 265-275
Function
Function in SwissProt
Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.
Biological Process
See also
Diagram with PDB data
VPS4/VTA1/DID4Vps4p-Vta1p complex with peptide binding to the central pore of Vps4p