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IID50387
 UniprotQ06696
ProteinVacuolar protein-sorting-associated protein 36
GeneVPS36
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
566
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-98,251-289 Hetero octamer :
 Evidence X-RAY 2cay A Reference
       Region 2cay A 1-98 order
       Region 2cay A 251-282 order
       Region 2cay A 283-289 disorder
 Evidence X-RAY 2cay B Reference
       Region 2cay B 1-98 order
Seq 1-566 Hetero tetramer : IID50371Complex,IID50389Complex
 Evidence X-RAY 1w7p D Reference
       Region 1w7p D 1-395 disorder
       Region 1w7p D 396-566 order
 Evidence X-RAY 1u5t B Reference
       Region 1u5t B 396-564 order
Seq 110-171 Hetero dimer : IID50383Complex
 Evidence X-RAY 2j9u B Reference
       Region 2j9u B 110-114 disorder
       Region 2j9u B 115-161 order
       Region 2j9u B 162-171 disorder
 Evidence X-RAY 2j9u D Reference
       Region 2j9u D 110-114 disorder
       Region 2j9u D 115-161 order
       Region 2j9u D 162-171 disorder
 
Prediction
NeProc
Disorder 97-113,146-182,189-199,206-252,286-319,338-341,358-362,370-404
Order 1-96,114-145,183-188,200-205,253-285,320-337,342-357,363-369,405-566
ProS 146-151,179-182,189-199,316-319,338-341,358-362,398-404
AlphaFold
Disorder 1-1,97-113,163-180,215-216,218-220,231-253,285-353,356-356,358-392,425-430,521-524,565-566
Order 2-96,114-162,181-214,217-217,221-230,254-284,354-355,357-357,393-424,431-520,525-564
Pfam Hmmer
PF04132 295-563 2.4e-05
SEG 238-252
Function
Function in SwissProt
Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:12194858, PubMed:15469844, PubMed:15329733). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:12194858). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (PubMed:12194858). Involved in the trafficking of the plasma membrane ATPase (PubMed:12194858). Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (PubMed:15029239).
Biological Process
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
See also
Diagram without PDB data
VPS20ESCRT-III recruitment