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IID50389
 UniprotQ12483
ProteinVacuolar-sorting protein SNF8
GeneSNF8
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
233
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-233 Hetero tetramer : IID50371Complex,IID50387Complex
 Evidence X-RAY 1w7p A Reference
       Region 1w7p A 1-19 disorder
       Region 1w7p A 20-232 order
       Region 1w7p A 233-233 disorder
 Evidence X-RAY 1u5t A Reference
       Region 1u5t A 1-19 disorder
       Region 1u5t A 20-232 order
       Region 1u5t A 233-233 disorder
 
Prediction
NeProc
Disorder 1-15
Order 16-233
ProS 1-15
AlphaFold
Disorder 1-3,5-6,8-8,55-55,74-89,230-233
Order 4-4,7-7,9-54,56-73,90-229
Pfam Hmmer
PF04157 85-233 2.1e-29
Function
Function in SwissProt
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
Biological Process
See also
Diagram with PDB data
VPS36/SNF8/VPS25/VPS25The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
Diagram without PDB data
VPS20ESCRT-III recruitment