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IID50391
 UniprotQ3SX13
ProteincAMP-dependent protein kinase inhibitor alpha
GenePKIA
OrganismBos taurus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
76
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-25 Hetero dimer : IID50134Complex
 Evidence X-RAY 2gnj I Reference
       Region 2gnj I 6-25 order
 Evidence X-RAY 2uzt B Reference
       Region 2uzt B 6-25 order
 Evidence X-RAY 2uzu I Reference
       Region 2uzu I 6-25 order
 Evidence X-RAY 2uzv 2 Reference
       Region 2uzv 2 6-25 order
 Evidence X-RAY 2uzw I Reference
       Region 2uzw I 6-25 order
 Evidence X-RAY 3e8c G Reference
       Region 3e8c G 6-23 order
       Region 3e8c G 24-25 disorder
 Evidence X-RAY 3e8c H Reference
       Region 3e8c H 6-25 order
 Evidence X-RAY 3e8c I Reference
       Region 3e8c I 6-25 order
 Evidence X-RAY 3e8c J Reference
       Region 3e8c J 6-24 order
       Region 3e8c J 25-25 disorder
 Evidence X-RAY 3e8c K Reference
       Region 3e8c K 6-25 order
 Evidence X-RAY 3e8c L Reference
       Region 3e8c L 6-6 disorder
       Region 3e8c L 7-25 order
 Evidence X-RAY 3e8e C Reference
       Region 3e8e C 6-25 order
 Evidence X-RAY 3e8e F Reference
       Region 3e8e F 6-25 order
 Evidence X-RAY 3e8e G Reference
       Region 3e8e G 6-25 order
 Evidence X-RAY 3e8e J Reference
       Region 3e8e J 6-25 order
 Evidence X-RAY 3e8e N Reference
       Region 3e8e N 6-25 order
 Evidence X-RAY 3e8e Q Reference
       Region 3e8e Q 6-25 order
 Evidence X-RAY 3zo1 I Reference
       Region 3zo1 I 6-23 order
 Evidence X-RAY 3zo2 I Reference
       Region 3zo2 I 6-23 order
       Region 3zo2 I 24-25 disorder
 Evidence X-RAY 3zo3 I Reference
       Region 3zo3 I 6-23 order
 Evidence X-RAY 3zo4 I Reference
       Region 3zo4 I 6-25 order
 Evidence X-RAY 4c33 I Reference
       Region 4c33 I 6-23 order
 Evidence X-RAY 4c34 I Reference
       Region 4c34 I 6-23 order
 Evidence X-RAY 4c35 I Reference
       Region 4c35 I 6-23 order
 Evidence X-RAY 4c36 I Reference
       Region 4c36 I 6-24 order
       Region 4c36 I 25-25 disorder
 Evidence X-RAY 4c37 I Reference
       Region 4c37 I 6-25 order
 Evidence X-RAY 4c38 I Reference
       Region 4c38 I 6-24 order
       Region 4c38 I 25-25 disorder
 Evidence X-RAY 4yxr I Reference
       Region 4yxr I 6-25 order
 Evidence X-RAY 5vhb B Reference
       Region 5vhb B 6-23 order
 Evidence X-RAY 5vi9 B Reference
       Region 5vi9 B 6-23 order
 Evidence X-RAY 5vib B Reference
       Region 5vib B 6-23 order
SeqProS possible 5-25 Same region of the rabbit ortholog (P61926, 98.7% identity) is disordered in the free state. Hetero dimer : IID50134Complex
       Region 4yxr I 6-25 order
       Region 4c37 I 6-25 order
       Region 4c35 I 6-23 order
       Region 2uzu I 6-25 order
       Region 3e8e C 6-25 order
       Region 3e8e F 6-25 order
       Region 3e8e G 6-25 order
       Region 3e8e J 6-25 order
       Region 3e8e N 6-25 order
       Region 3e8e Q 6-25 order
       Region 2gnj I 6-25 order
       Region 5vhb B 6-23 order
       Region 2uzw I 6-25 order
       Region 3zo2 I 6-23 order
       Region 4c38 I 6-24 order
       Region 3zo3 I 6-23 order
       Region 2uzv 2 6-25 order
       Region 4c36 I 6-24 order
       Region 5vi9 B 6-23 order
       Region 3zo4 I 6-25 order
       Region 2uzt B 6-25 order
       Region 3zo1 I 6-23 order
       Region 4c33 I 6-23 order
       Region 3e8c G 6-23 order
       Region 3e8c H 6-25 order
       Region 3e8c I 6-25 order
       Region 3e8c J 6-24 order
       Region 3e8c K 6-25 order
       Region 3e8c L 7-25 order
       Region 4c34 I 6-23 order
       Region 5vib B 6-23 order
Seqacetylation
    2-2 N-acetylthreonine
 
Prediction
NeProc
Disorder 1-9,20-23,30-76
Order 10-19,24-29
ProS 5-9,20-23,35-50
AlphaFold
Disorder 1-1,15-34,52-76
Order 2-14,35-51
Pfam Hmmer
PF02827 2-75 7.6e-48
Function
Function in SwissProt
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.