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IID50392
 UniprotQ5EBH1
ProteinRas association domain-containing protein 5
GeneRassf5
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
413
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 95-166 Monomer :
 Evidence NMR 1rfh A Reference
       Region 1rfh A 108-166 order
       Region 1rfh A 108-115 high_rmsd
 Evidence NMR 2fnf X Reference
       Region 2fnf X 95-107 disorder
       Region 2fnf X 108-166 order
       Region 2fnf X 108-115 high_rmsd
Seq 200-357 Hetero dimer : P01112
 Evidence X-RAY 3ddc B Reference
       Region 3ddc B 200-248 order
       Region 3ddc B 249-273 disorder
       Region 3ddc B 274-357 order
Seq 370-413 Homo dimer :
 Evidence X-RAY 2ymy B Reference
       Region 2ymy B 370-408 order
       Region 2ymy B 409-413 disorder
 Evidence X-RAY 2ymy A Reference
       Region 2ymy A 370-408 order
       Region 2ymy A 409-413 disorder
Seqphosphorylation
    177-177 Phosphoserine
    274-274 Phosphoserine
    347-347 Phosphothreonine
 
Prediction
NeProc
Disorder 1-112,161-225,232-267
Order 113-160,226-231,268-413
ProS 4-17,22-30,39-43,55-60,76-112,161-164,171-225,232-249,255-267
AlphaFold
Disorder 1-112,127-128,168-199,242-251,263-266,269-279,358-362,410-413
Order 113-126,129-167,200-241,252-262,267-268,280-357,363-409
Pfam Hmmer
PF00130 118-168 2.3e-11
PF00788 269-359 8.9e-13
SEG 31-39 ,49-67 ,76-90
Function
Function in SwissProt
Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.